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Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects.

Author(s): F. Ausubel, Laurence G Rahme, G Jander

Publication date: 2000-06-30

Keywords: Animals, Biological Assay, Humans, Mice, Moths, microbiology, Mutagenesis, Pseudomonas aeruginosa, genetics, growth & development, pathogenicity, Virulence

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Abstract

Strain PA14, a human clinical isolate of Pseudomonas aeruginosa, is pathogenic in mice and insects (Galleria mellonella). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa.

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PubMed ID:: 10851003

PMC ID:: 94559

DOI:: 10.1128/JB.182.13.3843-3845.2000

ScienceOpen disciplines: Chemistry

Keywords: Animals,Biological Assay,Humans,Mice,Moths,microbiology,Mutagenesis,Pseudomonas aeruginosa,genetics,growth & development,pathogenicity,Virulence

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ScienceOpen disciplines: Chemistry

Keywords: Animals, Biological Assay, Humans, Mice, Moths, microbiology, Mutagenesis, Pseudomonas aeruginosa, genetics, growth & development, pathogenicity, Virulence

Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects.

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Microbiology Independent Research Journal (MIR Journal)

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