For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
9
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
1 collections
    0
    shares
      13
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Intravital Microscopy Evidence That Methylene Blue Should Be a Vasopressor-Sparing Agent in Sepsis Vasoplegia

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Microvasculature failure is expected in sepsis and at higher amine concentrations. Therefore, special attention focused individually on microcirculation is needed. Here, we present that methylene blue can prevent leukocytes from adhering to the endothelium in a rat model of lipopolysaccharide-induced endotoxemia. As hypothesis evidence, an intravital microscopy image is presented.

          Related collections

          Most cited references9

          • Record: found
          • Abstract: found
          • Article: not found

          Catecholamine Vasopressor Support Sparing Strategies in Vasodilatory Shock.

          Mitchell S. Buckley, Jeffrey Barletta, Pamela Smithburger … (2019)
          Shock syndromes are associated with unacceptably high rates of mortality in critically ill patients despite advances in therapeutic options. Vasodilatory shock is the most common type encountered in the intensive care unit. It is manifested by cardiovascular failure, peripheral vasodilatation, and arterial hypotension leading to tissue hypoperfusion and organ failure. Hemodynamic support is typically initiated with fluid resuscitation strategies and administration of adrenergic vasopressor agents in nonresponsive patients to restore arterial pressure with subsequent adequate organ reperfusion. Unfortunately, high catecholamine dosing requirements may be necessary to achieve targeted hemodynamic goals that may increase the risk of vasopressor-induced adverse events. The purpose of this article is to review the clinical efficacy and safety data and potential role in therapy for catecholamine-sparing agents in vasodilatory shock. Adjunctive therapeutic options to reduce vasoactive support requirements without compromising arterial pressure include arginine vasopressin and analogs, corticosteroids, midodrine, methylene blue, and angiotensin II. Although concomitant vasopressin and corticosteroids have a more defined role in evidence-based guidelines for managing shock, clinicians may consider other potential catecholamine-sparing agents.
          Article 0 comments Cited 13 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Methylene blue administration in SIRS after cardiac operations.

            Alex de Crespigny, P Evora, Ricardo Ribeiro (1997)
            Article 0 comments Cited 12 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Impact of methylene blue in addition to norepinephrine on the intestinal microcirculation in experimental septic shock.

              Jordan Nantais, Tristan Dumbarton, Nizam Farah … (2014)
              Methylene blue (MB) has been used with some success as a treatment for the vasoplegia of vasopressor-refractory septic shock. The putative mechanism of action of MB is the inhibition of endothelial nitric oxide within the microvasculature and improved responsiveness to endogenous catecholamines (norepinephrine (NE)). However, to date, no study has demonstrated the microcirculatory effect of methylene blue in septic shock. The objective of this randomized, controlled, animal study was to show, in an experimentally-induced, septic shock model in rats, the effects of MB and NE on global hemodynamics and the microcirculation. Mean arterial pressure (MAP) was drastically reduced following bacterial endotoxin (lipopolysaccharide, LPS) administration in animals not receiving vasopressors. Only the combination of NE + MB restored MAP to control levels by the end of the three hour experiment. Intravital microscopy of the microcirculation was performed in the terminal ileum in order to examine functional capillary density in intestinal muscle layers and the mucosa, as well as leukocyte activation in venules (rolling, adhesion to the endothelium). Untreated LPS animals showed a significant increase in leukocyte adhesion and a decrease in capillary perfusion in the intestinal microcirculation. In groups receiving NE or NE+MB, we observed a significant decrease in leukocyte adhesion and improved functional capillary density, indicating that microvasculature function was improved. This study suggests that methylene blue may be able to improve hemodynamics while preserving microvascular function in septic shock.
              Article 0 comments Cited 6 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Fabiola Leslie Antunes Cardoso Mestriner: Role: Substantial contributions to the conception or design of the workRole: or the acquisitionRole: analysisRole: or interpretation of data for the workRole: drafting the work or revising it critically for important intellectual contentRole: final approval of the version to be publishedRole: agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved
                Pedro Brüch Dantas: Role: Substantial contributions to the conception or design of the workRole: or the acquisitionRole: analysisRole: or interpretation of data for the work
                Jéssyca Michelon Barbosa: Role: Substantial contributions to the conception or design of the workRole: or the acquisitionRole: analysisRole: or interpretation of data for the work
                Paulo Roberto B. Evora:
                ORCID: http://orcid.org/0000-0001-9631-946X
                Role: Substantial contributions to the conception or design of the workRole: or the acquisitionRole: analysisRole: or interpretation of data for the workRole: drafting the work or revising it critically for important intellectual contentRole: final approval of the version to be publishedRole: agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved
                Christiane Becari: Role: Substantial contributions to the conception or design of the workRole: or the acquisitionRole: analysisRole: or interpretation of data for the workRole: drafting the work or revising it critically for important intellectual contentRole: final approval of the version to be publishedRole: agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved
                Journal
                Journal ID (nlm-ta): Braz J Cardiovasc Surg
                Journal ID (iso-abbrev): Braz J Cardiovasc Surg
                Journal ID (publisher-id): rbccv
                Title: Brazilian Journal of Cardiovascular Surgery
                Publisher: Sociedade Brasileira de Cirurgia Cardiovascular
                ISSN (Print): 0102-7638
                ISSN (Electronic): 1678-9741
                Publication date (Electronic, pub): 20 March 2024
                Publication date (Electronic, collection): 2024
                Volume: 39
                Issue: 3
                Electronic Location Identifier: e20230066
                Affiliations
                [1 ] Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
                [2 ] Department of Biological Sciences, Faculdade de Odontologia de Bauru, Universidade de São Paulo, Bauru, São Paulo, Brazil
                Author notes
                Correspondence Address: Paulo Roberto B. Evora https://orcid.org/0000-0001-9631-946X Bandeirantes Av., 3900, Ribeirão Preto, SP, Brazil, Zip Code: 14049-900, E-mail: prbevora@ 123456fmrp.usp.br
                Author information
                http://orcid.org/0000-0001-9631-946X
                Article
                Other ID: 01000
                DOI: 10.21470/1678-9741-2023-0066
                PMC ID: 10989190
                PubMed ID: 38569061
                SO-VID: 7b065e43-09f0-418a-9c44-bdd5ea87c701
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 18 February 2023
                Date accepted : 04 September 2023
                Funding
                Funded by: CAPES
                Award ID: 2017/21539-7
                Award ID: 2018/23718-8
                Funded by: FAPESP
                Award ID: 2019/21721-4
                Categories
                Subject: Brief Communication

                Keywords: methylene blue,microcirculation,microvessels,endothelium,lipopolysaccharides
                Data availability:
                Keywords: methylene blue, microcirculation, microvessels, endothelium, lipopolysaccharides

                Comments

                Comment on this article