Plants must adapt to drought stress to survive. The phytohormone abscisic acid (ABA) is produced under drought stress conditions and is essential for the response to drought stress. The ABA level plays an important role in the response, and several enzymes for ABA biosynthesis and catabolism have been identified. Physiological studies have shown that several metabolites accumulate and function as osmolytes under drought stress conditions. Many drought-inducible genes with various functions have been identified, and transgenic plants that harbor these genes have shown increased tolerance to drought.