Functional cellulose-based hydrogels as extracellular matrices for tissue engineering

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Abstract

Cellulose-based hydrogels are immensely important for tissue engineering. In this review, we attempt to document the source, nature, and application of cellulose-based hydrogels as an extracellular matrix for tissue growth and regeneration. Hydrogels can be prepared either from native cellulose, including both bacterial and plant sources or from cellulose derivatives, such as methyl cellulose, carboxymethylcellulose, and hydroxypropylmethylcellulose or even metal ions such as silver. Cellulose-polymer composite (polymers that include natural sources including chitosan, starch, alginates, collagen, hyaluronic acid, and chitin) are an attractive, inexpensive, and advantageous structural material that is easy to use. Cellulose-based scaffolding materials are widely used in the regeneration of various tissues, such as bone, cartilage, heart, blood vessel, nerve, and liver, among others. In this review, we discuss the most important applications of cellulosic hydrogels in tissue engineering based on their structural compositions.

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Most cited references 148

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Hydrogels for tissue engineering.

Kuen Lee, David Mooney (2001)

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Hydrogels in pharmaceutical formulations.

N. Peppas (2000)

The availability of large molecular weight protein- and peptide-based drugs due to the recent advances in the field of molecular biology has given us new ways to treat a number of diseases. Synthetic hydrogels offer a possibly effective and convenient way to administer these compounds. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as pH, ionic strength and temperature. The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.

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Hydrogel nanoparticles in drug delivery.

Mehrdad Hamidi, Amir Azadi, Pedram Rafiei (2008)

Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system (e.g., hydrophilicity and extremely high water content) with a nanoparticle (e.g., very small size). Several polymeric hydrogel nanoparticulate systems have been prepared and characterized in recent years, based on both natural and synthetic polymers, each with its own advantages and drawbacks. Among the natural polymers, chitosan and alginate have been studied extensively for preparation of hydrogel nanoparticles and from synthetic group, hydrogel nanoparticles based on poly (vinyl alcohol), poly (ethylene oxide), poly (ethyleneimine), poly (vinyl pyrrolidone), and poly-N-isopropylacrylamide have been reported with different characteristics and features with respect to drug delivery. Regardless of the type of polymer used, the release mechanism of the loaded agent from hydrogel nanoparticles is complex, while resulting from three main vectors, i.e., drug diffusion, hydrogel matrix swelling, and chemical reactivity of the drug/matrix. Several crosslinking methods have been used in the way to form the hydrogel matix structures, which can be classified in two major groups of chemically- and physically-induced crosslinking.

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Author and article information

Contributors

Ki-Taek Lim:

ORCID: http://orcid.org/0000-0003-2091-788X

ktlim@kangwon.ac.kr

Journal

Journal ID (nlm-ta): J Biol Eng

Journal ID (iso-abbrev): J Biol Eng

Title: Journal of Biological Engineering

Publisher: BioMed Central (London )

ISSN (Electronic): 1754-1611

Publication date (Electronic): 20 June 2019

Publication date PMC-release: 20 June 2019

Publication date Collection: 2019

Volume: 13

Electronic Location Identifier: 55

Affiliations

[1 ]ISNI 0000 0001 0707 9039, GRID grid.412010.6, Biorobotics Laboratory, Department of Biosystems Engineering, , Kangwon National University, ; Chuncheon, Republic of Korea

[2 ]ISNI 0000 0001 0707 9039, GRID grid.412010.6, The Institute of Forest Science, , Kangwon National University, ; Chuncheon, 24341 Republic of Korea

Author information

Ki-Taek Lim http://orcid.org/0000-0003-2091-788X

Article

Publisher ID: 177

DOI: 10.1186/s13036-019-0177-0

PMC ID: 6585131

PubMed ID: 31249615

SO-VID: 7a81c194-3a2e-4864-b5a0-d049029b5e54

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 24 February 2019

Date accepted : 10 May 2019

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100003725, National Research Foundation of Korea;

Award ID: (No. 2018R1A6A1A03025582)& (NRF-2016R1D1 A3B03932921)

Award Recipient : Ki-Taek Lim

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ScienceOpen disciplines: Biotechnology

Keywords: cellulose,hydrogels,scaffolds,extracellular matrices,tissue engineering

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ScienceOpen disciplines: Biotechnology

Keywords: cellulose, hydrogels, scaffolds, extracellular matrices, tissue engineering

Functional cellulose-based hydrogels as extracellular matrices for tissue engineering

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Most cited references 148

Hydrogels for tissue engineering.

Hydrogels in pharmaceutical formulations.

Hydrogel nanoparticles in drug delivery.

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