Parsing Myc Paralogs in Oncogenesis.

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Abstract

Myc and its paralog MycN are thought to be functionally redundant, but Myc- and MycN-driven medulloblastomas exhibit distinct phenotypes. In this issue of Cancer Cell, Vo and colleagues (2016) show that this phenotypic difference stems from the preferential ability of Myc, relative to MycN, to bind Miz1 and repress transcription.

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PubMed ID:: 26766585

DOI:: 10.1016/j.ccell.2015.12.009

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Parsing Myc Paralogs in Oncogenesis.

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Cancer Immunotherapy

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