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      Effects of metabolic factors in mediating the relationship between Type 2 diabetes and depression in East Asian populations: A two-step, two-sample Mendelian randomization study.

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          Abstract

          Observational studies suggested a close link between type 2 diabetes (T2D), metabolic factors and depression, while the causal relationships remained poorly understood.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): J Affect Disord
          Title: Journal of affective disorders
          Publisher: Elsevier BV
          ISSN (Electronic): 1573-2517
          ISSN (Print): 0165-0327
          Publication date (Electronic): Aug 15 2023
          Volume: 335
          Affiliations
          [1 ] School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, Guangdong, China.
          [2 ] School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China.
          [3 ] School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, Guangdong, China.
          [4 ] Department of Endocrinology, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
          [5 ] Big Data Research Center, Fifth Hospital of Chongqing, Chongqing, China.
          [6 ] Guangzhou Centre for Applied Mathematics, Guangzhou University, Guangzhou, China. Electronic address: jiaof@gzhu.edu.cn.
          [7 ] Department of Endocrinology, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu, China. Electronic address: drzhong@163.com.
          [8 ] School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China; School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: jianggzh5@mail.sysu.edu.cn.
          Article
          Publisher Item ID: S0165-0327(23)00600-6
          DOI: 10.1016/j.jad.2023.04.114
          PubMed ID: 37150218
          SO-VID: 7a07cec6-59eb-4898-b8aa-fb07d4328743
          History

          Keywords: Blood pressure,Depression,Fasting insulin,Lipids,Mediation,Mendelian randomization,Type 2 diabetes
          Data availability:
          Keywords: Blood pressure, Depression, Fasting insulin, Lipids, Mediation, Mendelian randomization, Type 2 diabetes

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