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      Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76.

      1 ,
      Cold Spring Harbor perspectives in biology

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          Abstract

          The adaptor protein SLP-76 is expressed in multiple hematopoietic lineages including T cells, platelets, and neutrophils. SLP-76 mediated signaling is dependent on its multiple protein interaction domains, as it creates a scaffold on which key signaling complexes are built. SLP-76 is critical for supporting signaling downstream of both immunoreceptors and integrins. The signaling molecules used both upstream and downstream of SLP-76 are similar among these receptors and across cell types; however, important differences exist. Appreciating how SLP-76 coordinates signal transduction across different cell and receptor types provides insights into the complex interplay of pathways critical for activation of cells of the immune system that are essential for host defense.

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          Author and article information

          Journal
          Cold Spring Harb Perspect Biol
          Cold Spring Harbor perspectives in biology
          1943-0264
          1943-0264
          Apr 2010
          : 2
          : 4
          Affiliations
          [1 ] Abramson Family Cancer Institute, University of Pennsylvania, Philadelphia, 19104, USA.
          Article
          cshperspect.a002501
          10.1101/cshperspect.a002501
          2845197
          20452948
          79dd6aec-a48f-45a4-9202-e60309a64faa
          History

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