[1
]Cancer Genome Project, Wellcome Trust Sanger Institute, Genome Campus, Hinxton , Cambridgeshire CB10 1SA, UK
[2
]Lungs for Living Research Centre, Rayne Institute, University College London , London WC1E 6JF, UK
[3
]University of Cambridge , Cambridge CB2 0XY, UK
[4
]Departments of Pathology and Oncology, Johns Hopkins Medical Institutions , Baltimore, Maryland 21205, USA
[5
]Addenbrooke’s NHS Foundation Trust , Cambridge CB2 0QQ, UK
[6
]Children’s Brain Tumour Research Centre, University of Nottingham , Nottingham NG7 2UH, UK
[7
]Department of Pediatrics, Hospital for Sick Children, University of Toronto , Toronto, Ontario, Canada M5G 1X8
[8
]Institute for Cancer Research, Sutton , London SM2 5NG, UK
[9
]Dana-Farber Cancer Institute , Boston, Massachusetts 02215, USA
[10
]Royal National Orthopaedic Hospital , Middlesex HA7 4LP, UK
[11
]Peter MacCallum Cancer Centre , Melbourne, Victoria 3002, Australia
[12
]Department of Pathology, Jules Bordet Institute, 1000 Brussels, Belgium
[13
]Department of Pathology, Memorial-Sloan-Kettering Cancer Center , New York, New York 10065, USA
[14
]Department of Gastroenterology, Royal Melbourne Hospital, University of Melbourne , Parkville, Victoria 3050, Australia
[15
]National Institute of Environmental Health Sciences, Research Triangle Park , North Carolina 27713, USA
[16
]UNC Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, North Carolina 27599, USA
[17
]Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation
Trust and NIHR Cambridge Biomedical Research Centre , Cambridge CB2 0QQ, UK
[18
]Department of Pathology, Academic Medical Center , Meibergdreef 9, 1105 Amsterdam, AZ, The Netherlands
[19
]Department of Cancer Biology, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA
[20
]Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School , 75 Francis Street, Boston, Massachusetts 02115, USA
[21
]East of Scotland Breast Service, Ninewells Hospital , Dundee DD1 9SY, UK
[22
]Department of Research Oncology, Guy’s Hospital, King’s Health Partners AHSC, King’s
College London School of Medicine , London SE1 9RT, UK
[23
]Institut Bergonié , 229 cours de l’Argone, 33076 Bordeaux, France
[24
]Institut Curie, Department of Tumor Biology , 26 rue d’Ulm, 75248 Paris cédex 05, France
[25
]Institut Curie, INSERM Unit 830 , 26 rue d’Ulm, 75248 Paris cédex 05, France
[26
]Department of Pathology, Jules Bordet Institute , 1000 Brussels, Belgium
[27
]Department of Pathology, Skåne University Hospital, Lund University , SE-221 85 Lund, Sweden
[28
]Department of Pathology, Oslo University Hospital Ulleval and University of Oslo,
Faculty of Medicine and Institute of Clinical Medicine , 0450 Oslo, Norway
[29
]Lund University, Division of Oncology, Department of Clinical Sciences, Lund University
Cancer Center at Medicon Village , Lund SE-223 81, Sweden
[30
]Blekinge Hospital, Department of Pathology and Cytology , SE-371 85 Karlskrona, Sweden
[31
]Translational Cancer Research Unit , GZA Hospitals St Augustinus, 2610 Antwerp, Belgium
[32
]Department of Pathology, Erasmus Medical Center , 3015 Rotterdam, The Netherlands
[33
]The University of Queensland, School of Medicine, Herston, Brisbane, Queensland 4006,
Australia
[34
]Pathology Queensland: The Royal Brisbane & Women’s Hospital , Brisbane, Queensland 4029, Australia
[35
]The University of Queensland, UQ Centre for Clinical Research, Herston , Brisbane, Queensland 4029, Australia
[36
]Department of Pathology, Memorial Sloan-Kettering Cancer Center , New York, New York 10065, USA
[37
]Centre Georges-François Leclerc , 1 rue du Professeur Marion, 21079 Dijon, France
[38
]0nstitut Paoli Calmettes, Department of Biopathology , 232 Boulevard Sainte Marguerite, 13009 Marseille, France
[39
]Centre Léon Bérard, Lyon, France; Université Claude Bernard Lyon1—Université de Lyon,
69008 Lyon, France
[40
]Department of Oncology, University of Cambridge and Cancer Research UK Cambridge Research
Institute, Li Ka Shin Centre , Cambridge CB2 0RE, UK
[41
]Dundee Cancer Centre, Ninewells Hospital , Dundee DD1 9SY, UK
[42
]Erasmus MC Cancer Institute, Erasmus University Medical Center , 3015 Rotterdam, The Netherlands
[43
]Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen
Centre for Molecular Life Sciences , 6500 HB Nijmegen, The Netherlands
[44
]Department of Radiation Oncology, Radboud University Medical Centre , 6500 Nijmegen, The Netherlands
[45
]Department of Laboratory Medicine, Radboud University Medical Centre , 6500 Nijmegen, The Netherlands
[46
]Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université
Libre de Bruxelles , 1000 Brussels, Belgium
[47
]Universite Lyon1, INCa-Synergie, Centre Leon Berard , 28 rue Laennec, 69008 Lyon, France
[48
]Department Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
[49
]Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital,
Oslo University Hospital , O310 Oslo, Norway
[50
]Department of Molecular Oncology, BC Cancer Agency , 675 W10th Avenue, Vancouver, British Columbia, Canada V5Z 1L3
[51
]The Netherlands Cancer Institute, Division of Molecular Carcinogenesis , 1066 Amsterdam, The Netherlands
[52
]Department of Surgery, University of California, San Francisco , San Francisco, California 94143, USA
[53
]Cancer Research Laboratory, Faculty of Medicine, University of Iceland , 101 Reykjavik, Iceland
[54
]Department of Pathology, University Hospital , 101 Reykjavik, Iceland
[55
]Icelandic Cancer Registry, Icelandic Cancer Society , Skogarhlid 8, P.O. Box 5420, 125 Reykjavik, Iceland
[56
]Institute for Clinical Medicine, Faculty of Medicine, University of Oslo , 0450 Oslo, Norway
[57
]National Genotyping Center, Institute of Biomedical Sciences, Academia Sinica , 128 Academia Road, Sec 2, Nankang, Taipei 115, Taiwan, China
[58
]NCCS-VARI Translational Research Laboratory, National Cancer Centre Singapore , 11 Hospital Drive, 169610 Singapore, Singapore
[59
]Department of General Surgery, Singapore General Hospital , 169608 Singapore, Singapore
Germline pseudogenes have an important role in human evolution. Here, the authors
analyse sequencing data from 660 cancer samples and find evidence for the formation
of somatically acquired pseudogenes, a new class of mutation, which may contribute
to cancer development.
