Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis and regulates iron metabolism. Additional data are needed regarding the effectiveness and safety of roxadustat as compared with standard therapy (epoetin alfa) for the treatment of anemia in patients undergoing dialysis.

Related collections

Most cited references 24

Record: found
Abstract: found
Article: not found

Mechanisms of anemia in CKD.

Jodie L. Babitt, Herbert Y. Lin (2012)

Anemia is a common feature of CKD associated with poor outcomes. The current management of patients with anemia in CKD is controversial, with recent clinical trials demonstrating increased morbidity and mortality related to erythropoiesis stimulating agents. Here, we examine recent insights into the molecular mechanisms underlying anemia of CKD. These insights hold promise for the development of new diagnostic tests and therapies that directly target the pathophysiologic processes underlying this form of anemia.

0 comments Cited 341 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis

Nan Chen, Chuanming Hao, Xiaomei Peng … (2019)

0 comments Cited 222 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Hypoxia-inducible factor 1: master regulator of O2 homeostasis.

Gregg L. Semenza (1998)

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.

0 comments Cited 217 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: New England Journal of Medicine

Abbreviated Title: N Engl J Med

Publisher: Massachusetts Medical Society

ISSN (Print): 0028-4793

ISSN (Electronic): 1533-4406

Publication date Created: July 24 2019

Publication date (Electronic): July 24 2019

Affiliations

[1 ]From the Department of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (N.C.), the Division of Nephrology, Huashan Hospital Fudan University (C.H.), and the Department of Nephrology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (G.J.), Shanghai, the Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine (B.-C.L.), the Department of Nephrology, First Affiliated Hospital (Jiangsu Province...