Research trends and hotspots of circular RNA in cardiovascular disease: A bibliometric analysis

Abstract

From a global perspective, cardiovascular diseases (CVDs), the leading factor accounting for population mortality, and circRNAs, RNA molecules with stable closed-loop structures, have been proven to be closely related. The latent clinical value and the potential role of circRNAs in CVDs have been attracting increasing, active research interest, but bibliometric studies in this field are still lacking. Thus, in this study, we conducted a bibliometric analysis by using software such as VOSviewer, CiteSpace, Microsoft Excel, and the R package to determine the current research progress and hotspots and ultimately provide an overview of the development trends and future frontiers in this field. In our study, based on our search strategy, a total of 1206 publications published before July 31, 2023 were accessed from the WOSCC database. According to our findings, there is a notable increasing trend in global publications in the field of circRNA in CVDs. China was found to be the dominant country in terms of publication number, but a lack of high-quality articles was a significant fault. A cluster analysis on the co-cited references indicated that dilated cardiomyopathy, AMI, and cardiac hypertrophy are the greatest objects of concern. In contrast, a keywords analysis indicated that high importance has been ascribed to MI, abdominal aortic aneurysm, cell proliferation, and coronary artery diseases.

Highlights

• •

  CircRNAs in CVDs have been an active research interest.

• •

  CircRNAs in dilated cardiomyopathy, AMI, and cardiac hypertrophy are with greatest concern.

• •

  The role of circRNAs in CVDs and its molecular mechanism are the current research orientation.

• •

  The potential of circRNAs as therapeutic targets or remedies for CVDs is the research hot spot.

• •

  CircRNAs translating polypeptides hasn't yet been widely studied in CVD, holding great value to be further discussed.