The role of PKC signaling in CRF-induced modulation of startle.

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Abstract

Hypersignaling of corticotropin releasing factor (CRF) has been implicated in stress disorders; however, many of its downstream mechanisms of action remain unclear. In vitro, CRF1 receptor activation initiates multiple cell signaling cascades, including protein kinase A (PKA), protein kinase C (PKC), and mitogen-activated protein kinase kinase MEK1/2 signaling. It is unclear, however, which of these signaling cascades mediate CRF-induced behaviors during stress.

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Journal

Journal ID (iso-abbrev): Psychopharmacology (Berl)

Title: Psychopharmacology

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1432-2072

ISSN (Print): 0033-3158

Publication date (Electronic): Oct 2013

Volume: 229

Issue: 4

Affiliations

[1 ] Center of Excellence for Stress and Mental Health, Veterans Affairs Hospital, La Jolla, CA, USA.

Article

Mid ID: NIHMS487371

DOI: 10.1007/s00213-013-3114-9

PMC ID: 3784645

PubMed ID: 23722830

SO-VID: 790d1f30-3903-48dd-8d27-67a76d6a2317

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