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      • Record: found
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      Alexithymia and somatization in agenesis of the corpus callosum

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          Abstract

          Deficient communication between the cerebral hemispheres is one of several prevailing neurobiological explanations for alexithymia and has been strongly supported by research on patients with commissurotomy. We examined self-reported symptoms of alexithymia in adults with agenesis of the corpus callosum (AgCC), a condition characterized by more subtle reductions in interhemispheric transfer than in commissurotomy. Sixteen adults with AgCC and full-scale intelligence quotient >80 were compared with 15 neurotypical controls group-matched for age and intelligence score. The AgCC group endorsed greater difficulty identifying and describing feelings and more vague physical symptoms than controls but similar levels of emotional experience and emotional coping. This finding of impaired emotional interpretation with intact emotional experience is consistent with findings in callosotomy patients, implicating the critical role of the corpus callosum in cognitive dimensions of emotion processing. Further study of alexithymia in AgCC using task-based measures may help clarify the nature of this relationship.

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          Development and validation of brief measures of positive and negative affect: The PANAS scales.

          David Watson, Lee Anna Clark, Auke Tellegen (1988)
          In recent studies of the structure of affect, positive and negative affect have consistently emerged as two dominant and relatively independent dimensions. A number of mood scales have been created to measure these factors; however, many existing measures are inadequate, showing low reliability or poor convergent or discriminant validity. To fill the need for reliable and valid Positive Affect and Negative Affect scales that are also brief and easy to administer, we developed two 10-item mood scales that comprise the Positive and Negative Affect Schedule (PANAS). The scales are shown to be highly internally consistent, largely uncorrelated, and stable at appropriate levels over a 2-month time period. Normative data and factorial and external evidence of convergent and discriminant validity for the scales are also presented.
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            The RAND 36-Item Health Survey 1.0.

            Ron D Hays, Cathy Donald Sherbourne, Rebecca M. Mazel (1993)
            Recently, Ware and Sherbourne published a new short-form health survey, the MOS 36-Item Short-Form Health Survey (SF-36), consisting of 36 items included in long-form measures developed for the Medical Outcomes Study. The SF-36 taps eight health concepts: physical functioning, bodily pain, role limitations due to physical health problems, role limitations due to personal or emotional problems, general mental health, social functioning, energy/fatigue, and general health perceptions. It also includes a single item that provides an indication of perceived change in health. The SF-36 items and scoring rules are distributed by MOS Trust, Inc. Strict adherence to item wording and scoring recommendations is required in order to use the SF-36 trademark. The RAND 36-Item Health Survey 1.0 (distributed by RAND) includes the same items as those in the SF-36, but the recommended scoring algorithm is somewhat different from that of the SF-36. Scoring differences are discussed here and new T-scores are presented for the 8 multi-item scales and two factor analytically-derived physical and mental health composite scores.
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              Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity.

              Lynn Paul, Warren S Brown, Ralph Adolphs … (2007)
              Agenesis of the corpus callosum (AgCC), a failure to develop the large bundle of fibres that connect the cerebral hemispheres, occurs in 1:4000 individuals. Genetics, animal models and detailed structural neuroimaging are now providing insights into the developmental and molecular bases of AgCC. Studies using neuropsychological, electroencephalogram and functional MRI approaches are examining the resulting impairments in emotional and social functioning, and have begun to explore the functional neuroanatomy underlying impaired higher-order cognition. The study of AgCC could provide insight into the integrated cerebral functioning of healthy brains, and may offer a model for understanding certain psychiatric illnesses, such as schizophrenia and autism.
              Article 0 comments Cited 197 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Lynn K Paul:
                ORCID: https://orcid.org/0000-0002-3128-8313
                Shawneen R Pazienza
                Warren S Brown:
                ORCID: https://orcid.org/0000-0001-6142-5588
                Journal
                Journal ID (nlm-ta): Soc Cogn Affect Neurosci
                Journal ID (iso-abbrev): Soc Cogn Affect Neurosci
                Journal ID (publisher-id): scan
                Title: Social Cognitive and Affective Neuroscience
                Publisher: Oxford University Press (UK )
                ISSN (Print): 1749-5016
                ISSN (Electronic): 1749-5024
                Publication date Collection: October 2021
                Publication date (Electronic): 11 May 2021
                Publication date PMC-release: 11 May 2021
                Volume: 16
                Issue: 10
                Pages: 1071-1078
                Affiliations
                departmentDivision of Humanities and Social Sciences, California Institute of Technology , Pasadena, CA 91125, USA
                departmentFuller Graduate School of Psychology, Travis Research Institute , Pasadena, CA 91101, USA
                International Research Consortium for the Corpus Callosum and Cerebral Connectivity (IRC5) , Pasadena, CA 91106, USA
                Austin Outpatient Clinic, Central Texas Veterans Health Care System , Austin, TX 78744, USA
                departmentFuller Graduate School of Psychology, Travis Research Institute , Pasadena, CA 91101, USA
                International Research Consortium for the Corpus Callosum and Cerebral Connectivity (IRC5) , Pasadena, CA 91106, USA
                Author notes
                Correspondence should be addressed to Lynn K. Paul, California Institute of Technology, Division of Humanities and Social Sciences, Baxter MC 228-77, Pasadena, CA 91125, USA. E-mail: lkpaul@ 123456hss.caltech.edu .
                Author information
                https://orcid.org/0000-0002-3128-8313
                https://orcid.org/0000-0001-6142-5588
                Article
                Publisher ID: nsab056
                DOI: 10.1093/scan/nsab056
                PMC ID: 8483281
                PubMed ID: 33973635
                SO-VID: 7843ba05-05c8-4adc-843d-61b71995fc68
                Copyright © © The Author(s) 2021. Published by Oxford University Press.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

                History
                Date received : 12 August 2020
                Date revision received : 02 March 2021
                Date accepted : 11 May 2021
                Date: 30 April 2021
                Date: 28 September 2021
                Page count
                Pages: 8
                Funding
                Funded by: Eunice Kennedy Shriver National Institute of Child Health and Human Development, DOI 10.13039/100009633;
                Award ID: R15 HD33118-01A1
                Categories
                Subject: Original Manuscript
                Subject: AcademicSubjects/SCI01880

                ScienceOpen disciplines: Neurosciences
                Keywords: emotion,alexithymia,somatic complaints,corpus callosum,connectivity
                Data availability:
                ScienceOpen disciplines: Neurosciences
                Keywords: emotion, alexithymia, somatic complaints, corpus callosum, connectivity

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