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      Achieving biocompatible stiffness in NiTi through additive manufacturing

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          Abstract

          This article seeks to reduce the stiffness of NiTi parts from a nonporous state to that of human bone by introducing porosity. Compact bone stiffness is between 12 and 20 GPa while the currently used bone implant materials are several times stiffer. While very stiff implants and/or fixation hardware can temporarily immobilize healing bone, it also causes stress shielding of the surrounding bone and commonly results in stress concentrations at the implant or immobilization hardware’s fixation site(s). Together these processes can lead to implant or fixation hardware and/or the surrounding bone’s failure. Porous NiTi can be used to reduce the stiffness of metallic implants while also providing necessary stabilization or immobilization of the patient’s reconstructed anatomy. In this work, mechanical behavior of porous NiTi with different levels of porosity is simulated to show the relation between the stiffness and porosity level. Then porous structures are fabricated through additive manufacturing to validate the simulation results. The results indicate that stiffness can be reduced from the bulk value of 69 GPa to as low as 20.5 GPa for 58% porosity. The simulation shows that it is possible to achieve a wide range of desired stiffness by adjusting the level of porosity.

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          The effect of pore geometry on the in vitro biological behavior of human periosteum-derived cells seeded on selective laser-melted Ti6Al4V bone scaffolds.

          The specific aim of this study was to gain insight into the influence of scaffold pore size, pore shape and permeability on the in vitro proliferation and differentiation of three-dimensional (3-D) human periosteum-derived cell (hPDC) cultures. Selective laser melting (SLM) was used to produce six distinct designed geometries of Ti6Al4V scaffolds in three different pore shapes (triangular, hexagonal and rectangular) and two different pore sizes (500 μm and 1000 μm). All scaffolds were characterized by means of two-dimensional optical microscopy, 3-D microfocus X-ray computed tomography (micro-CT) image analysis, mechanical compression testing and computational fluid dynamical analysis. The results showed that SLM was capable of producing Ti6Al4V scaffolds with a broad range of morphological and mechanical properties. The in vitro study showed that scaffolds with a lower permeability gave rise to a significantly higher number of cells attached to the scaffolds after seeding. Qualitative analysis by means of live/dead staining and scanning electron micrography showed a circular cell growth pattern which was independent of the pore size and shape. This resulted in pore occlusion which was found to be the highest on scaffolds with 500 μm hexagonal pores. Interestingly, pore size but not pore shape was found to significantly influence the growth of hPDC on the scaffolds, whereas the differentiation of hPDC was dependent on both pore shape and pore size. The results showed that, for SLM-produced Ti6Al4V scaffolds with specific morphological and mechanical properties, a functional graded scaffold will contribute to enhanced cell seeding and at the same time can maintain nutrient transport throughout the whole scaffold during in vitro culturing by avoiding pore occlusion.
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            Manufacturing and processing of NiTi implants: A review

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              Relationship between unit cell type and porosity and the fatigue behavior of selective laser melted meta-biomaterials.

              Meta-materials are structures when their small-scale properties are considered, but behave as materials when their homogenized macroscopic properties are studied. There is an intimate relationship between the design of the small-scale structure and the homogenized properties of such materials. In this article, we studied that relationship for meta-biomaterials that are aimed for biomedical applications, otherwise known as meta-biomaterials. Selective laser melted porous titanium (Ti6Al4V ELI) structures were manufactured based on three different types of repeating unit cells, namely cube, diamond, and truncated cuboctahedron, and with different porosities. The morphological features, static mechanical properties, and fatigue behavior of the porous biomaterials were studied with a focus on their fatigue behavior. It was observed that, in addition to static mechanical properties, the fatigue properties of the porous biomaterials are highly dependent on the type of unit cell as well as on porosity. None of the porous structures based on the cube unit cell failed after 10(6) loading cycles even when the applied stress reached 80% of their yield strengths. For both other unit cells, higher porosities resulted in shorter fatigue lives for the same level of applied stress. When normalized with respect to their yield stresses, the S-N data points of structures with different porosities very well (R(2)>0.8) conformed to one single power law specific to the type of the unit cell. For the same level of normalized applied stress, the truncated cuboctahedron unit cell resulted in a longer fatigue life as compared to the diamond unit cell. In a similar comparison, the fatigue lives of the porous structures based on both truncated cuboctahedron and diamond unit cells were longer than that of the porous structures based on the rhombic dodecahedron unit cell (determined in a previous study). The data presented in this study could serve as a basis for design of porous biomaterials as well as for corroboration of relevant analytical and computational models.
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                Author and article information

                Journal
                Journal of Intelligent Material Systems and Structures
                Journal of Intelligent Material Systems and Structures
                SAGE Publications
                1045-389X
                1530-8138
                November 2016
                July 28 2016
                November 2016
                : 27
                : 19
                : 2661-2671
                Affiliations
                [1 ]Department of Mechanical, Industrial and Manufacturing Engineering, The University of Toledo, Toledo, OH, USA
                [2 ]S.M. Wu Manufacturing Research Center, Department of Mechanical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA
                [3 ]Department of Plastic Surgery, The Ohio State University, Columbus, OH, USA
                [4 ]Department of Mechanical Engineering, Kerman Graduate University of Advanced Technology, Kerman, Iran
                [5 ]Department of Mechanical Engineering, University of Kentucky, Lexington, KY, USA
                [6 ]Department of Mechanical Engineering, Isfahan University of Technology, Isfahan, Iran
                Article
                10.1177/1045389X16641199
                772b6961-c6f1-4f87-88dd-2c5310188e46
                © 2016

                http://journals.sagepub.com/page/policies/text-and-data-mining-license

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