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      Testosterone's Role in COVID-19

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The coronavirus disease 2019 (COVID-19) consistently displays a higher mortality in males. This sex-specific difference in outcomes is seen not only in the current COVID-19 pandemic, but also in prior viral epidemics and pandemics. Sex hormones, such as testosterone, play a clear role in modulating the immune response, providing a clue that may illuminate the underpinnings of these outcomes. Developing a deeper understanding of these epidemiological findings permits a more effective response to the disease. This article summarizes the sex-specific COVID-19 outcomes, the role of androgens in generating these outcomes, and the potential role of modifying testosterone levels as a form of treatment of COVID-19.

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          Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

          Dawei Wang, Bo Hu, Fangfang Zhu … (2020)
          In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.
          Article 0 comments Cited 11053 times – based on 0 reviews     Review now
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            SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

            Markus Hoffmann, Hannah Kleine-Weber, Simon Schroeder … (2020)
            Summary The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host cell proteases. Unravelling which cellular factors are used by SARS-CoV-2 for entry might provide insights into viral transmission and reveal therapeutic targets. Here, we demonstrate that SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. Finally, we show that the sera from convalescent SARS patients cross-neutralized SARS-2-S-driven entry. Our results reveal important commonalities between SARS-CoV-2 and SARS-CoV infection and identify a potential target for antiviral intervention.
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              Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

              Zunyou Wu, Jennifer M. McGoogan (2020)
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Sex Med
                Journal ID (iso-abbrev): J Sex Med
                Title: The Journal of Sexual Medicine
                Publisher: Published by Elsevier Inc. on behalf of International Society for Sexual Medicine.
                ISSN (Print): 1743-6095
                ISSN (Electronic): 1743-6109
                Publication date PMC-release: 19 March 2021
                Publication date (Electronic): 19 March 2021
                Affiliations
                [0001]Baylor College of Medicine, Houston, TX, USA
                Author notes
                [* ] Corresponding Author: Mohit Khera, MD, MBA, MPH, Professor, Urology, Baylor College of Medicine, 7200 Cambridge, Suite 10B, Houston, TX 77030. Tel.: (713) 798-4001.
                Article
                Publisher Item ID: S1743-6095(21)00305-2
                DOI: 10.1016/j.jsxm.2021.03.004
                PMC ID: 7972673
                PubMed ID: 33903045
                SO-VID: 7642f875-1346-46a0-8fd1-629d05ed1e61
                Copyright © © 2021 Published by Elsevier Inc. on behalf of International Society for Sexual Medicine.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                Date received : 30 November 2020
                Date accepted : 13 March 2021
                Categories
                Subject: Expert Opinion

                ScienceOpen disciplines: Sexual medicine
                Keywords: coronavirus,hypogonadism,androgens,immune system,cytokines
                Data availability:
                ScienceOpen disciplines: Sexual medicine
                Keywords: coronavirus, hypogonadism, androgens, immune system, cytokines

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