For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
1
views
146
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      370
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Therapeutic role of neural stem cells in neurological diseases

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The failure of endogenous repair is the main feature of neurological diseases that cannot recover the damaged tissue and the resulting dysfunction. Currently, the range of treatment options for neurological diseases is limited, and the approved drugs are used to treat neurological diseases, but the therapeutic effect is still not ideal. In recent years, different studies have revealed that neural stem cells (NSCs) have made exciting achievements in the treatment of neurological diseases. NSCs have the potential of self-renewal and differentiation, which shows great foreground as the replacement therapy of endogenous cells in neurological diseases, which broadens a new way of cell therapy. The biological functions of NSCs in the repair of nerve injury include neuroprotection, promoting axonal regeneration and remyelination, secretion of neurotrophic factors, immune regulation, and improve the inflammatory microenvironment of nerve injury. All these reveal that NSCs play an important role in improving the progression of neurological diseases. Therefore, it is of great significance to better understand the functional role of NSCs in the treatment of neurological diseases. In view of this, we comprehensively discussed the application and value of NSCs in neurological diseases as well as the existing problems and challenges.

          Related collections

          Most cited references146

          • Record: found
          • Abstract: found
          • Article: not found

          Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

          Kazutoshi Takahashi, Shinya Yamanaka (2006)
          Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers. Following injection into blastocysts, iPS cells contributed to mouse embryonic development. These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors.
          Article 0 comments Cited 2811 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

            Evandro F Fang, Yujun Hou, Konstantinos Palikaras … (2019)
            Accumulation of damaged mitochondria is a hallmark of aging and age-related neurodegeneration, including Alzheimer's disease (AD). The molecular mechanisms of impaired mitochondrial homeostasis in AD are being investigated. Here we provide evidence that mitophagy is impaired in the hippocampus of AD patients, in induced pluripotent stem cell-derived human AD neurons, and in animal AD models. In both amyloid-β (Aβ) and tau Caenorhabditis elegans models of AD, mitophagy stimulation (through NAD+ supplementation, urolithin A, and actinonin) reverses memory impairment through PINK-1 (PTEN-induced kinase-1)-, PDR-1 (Parkinson's disease-related-1; parkin)-, or DCT-1 (DAF-16/FOXO-controlled germline-tumor affecting-1)-dependent pathways. Mitophagy diminishes insoluble Aβ1-42 and Aβ1-40 and prevents cognitive impairment in an APP/PS1 mouse model through microglial phagocytosis of extracellular Aβ plaques and suppression of neuroinflammation. Mitophagy enhancement abolishes AD-related tau hyperphosphorylation in human neuronal cells and reverses memory impairment in transgenic tau nematodes and mice. Our findings suggest that impaired removal of defective mitochondria is a pivotal event in AD pathogenesis and that mitophagy represents a potential therapeutic intervention.
            Article 0 comments Cited 538 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Forcing cells to change lineages.

              Thomas Graf, Tariq Enver (2009)
              The ability to produce stem cells by induced pluripotency (iPS reprogramming) has rekindled an interest in earlier studies showing that transcription factors can directly convert specialized cells from one lineage to another. Lineage reprogramming has become a powerful tool to study cell fate choice during differentiation, akin to inducing mutations for the discovery of gene functions. The lessons learnt provide a rubric for how cells may be manipulated for therapeutic purposes.
              Article 0 comments Cited 315 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Ling Yang: Role: Role:
                Si-Cheng Liu: URI : https://loop.frontiersin.org/people/1699018/overviewRole: Role: Role: Role:
                Yi-Yi Liu: Role: Role:
                Fu-Qi Zhu: Role: Role: Role:
                Mei-Juan Xiong: Role: Role:
                Dong-Xia Hu: Role: Role: Role: Role: Role:
                Wen-Jun Zhang: URI : https://loop.frontiersin.org/people/2345934/overview
                Journal
                Journal ID (nlm-ta): Front Bioeng Biotechnol
                Journal ID (iso-abbrev): Front Bioeng Biotechnol
                Journal ID (publisher-id): Front. Bioeng. Biotechnol.
                Title: Frontiers in Bioengineering and Biotechnology
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 2296-4185
                Publication date (Electronic): 07 March 2024
                Publication date Collection: 2024
                Volume: 12
                Electronic Location Identifier: 1329712
                Affiliations
                [1] 1 Department of Rehabilitation Medicine , The Second Affiliated Hospital , Nanchang University , Nanchang, Jiangxi, China
                [2] 2 Department of Physical Examination , The Second Affiliated Hospital , Nanchang University , Nanchang, Jiangxi, China
                [3] 3 The Second Affiliated Hospital , Nanchang University , Nanchang, Jiangxi, China
                Author notes

                Edited by: Silvia Barbon, University of Padua, Italy

                Reviewed by: Elham Jamshidi, Johns Hopkins University, United States

                Pier Paolo Parnigotto, Foundation for Biology and Regenerative Medicine, Italy

                *Correspondence: Wen-Jun Zhang, ndefy22057@ 123456ncu.edu.cn ; Dong-Xia Hu, hudongxia5489@ 123456sina.com
                Article
                Publisher ID: 1329712
                DOI: 10.3389/fbioe.2024.1329712
                PMC ID: 10955145
                PubMed ID: 38515621
                SO-VID: 75ef3f54-3bdb-4730-9ba4-c53737f1e6ba
                Copyright © Copyright © 2024 Yang, Liu, Liu, Zhu, Xiong, Hu and Zhang.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 02 November 2023
                Date accepted : 12 February 2024
                Funding
                The author(s) declare financial support was received for the research, authorship, and/or publication of this article. These studies were supported by grants from the Natural Science Foundation of Jiangxi Province (20232BAB206048), Youth Science Foundation of Jiangxi Province (20224BAB216030).
                Categories
                Subject: Bioengineering and Biotechnology
                Subject: Review
                Custom metadata
                section-at-acceptance Tissue Engineering and Regenerative Medicine

                Keywords: nscs,neurological diseases,treatment,transplantation,challenge
                Data availability:
                Keywords: nscs, neurological diseases, treatment, transplantation, challenge

                Comments

                Comment on this article