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Proinflammatory S100A12 can activate human monocytes via Toll-like receptor 4.
Dirk Foell
1 ,
Helmut Wittkowski ,
Christoph Kessel ,
Aloys Lüken ,
Toni Weinhage ,
Georg Varga ,
Thomas Vogl ,
Timo Wirth ,
Dorothee Viemann ,
Per Björk ,
Marieke A D van Zoelen ,
Faekah Gohar ,
Geetha Srikrishna ,
Matthias Kraft ,
Johannes Roth
Jun 15 2013
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Abstract
S100A12 is overexpressed during inflammation and is a marker of inflammatory disease. Furthermore, it has been ascribed to the group of damage-associated molecular pattern molecules that promote inflammation. However, the exact role of human S100A12 during early steps of immune activation and sepsis is only partially described thus far.
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