New use of BCG for recombinant vaccines.

Stover, C. K.; de la Cruz, V F; Fuerst, T. R.; Burlein, J E; Benson, L A; Bennett, L T; Bansal, G P; Young, J F; Lee, M H; Hatfull, G. F.

doi:10.1038/351456a0

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New use of BCG for recombinant vaccines.

Author(s): C K Stover, V F de la Cruz, T R Fuerst, J E Burlein, L A Benson, L T Bennett, G P Bansal, J F Young, M H Lee, G F Hatfull

Publication date: 1991-06-06

Journal: Nature

Publisher: Springer Science and Business Media LLC

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Abstract

BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.