Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

Author(s): Yun Dai ¹ ^, ² ^, ³ , Yifan Guo ⁴ , Weicheng Tang ¹ ^, ² ^, ³ , Dan Chen ¹ ^, ² ^, ³ , Liru Xue ¹ ^, ² ^, ³ , Ying Chen ¹ ^, ² ^, ³ , Yican Guo ¹ ^, ² ^, ³ , Simin Wei ¹ ^, ² ^, ³ , Meng Wu ¹ ^, ² ^, ³ ^, , Jun Dai ¹ ^, ² ^, ³ ^, , Shixuan Wang ¹ ^, ² ^, ³ ^,

Publication date (Electronic): 15 May 2024

Journal: Journal of Nanobiotechnology

Publisher: BioMed Central

Keywords: Aging, Age-related disease, Nanomaterials, Antioxidant, Reactive oxygen species

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Abstract

With increasing proportion of the elderly in the population, age-related diseases (ARD) lead to a considerable healthcare burden to society. Prevention and treatment of ARD can decrease the negative impact of aging and the burden of disease. The aging rate is closely associated with the production of high levels of reactive oxygen species (ROS). ROS-mediated oxidative stress in aging triggers aging-related changes through lipid peroxidation, protein oxidation, and DNA oxidation. Antioxidants can control autoxidation by scavenging free radicals or inhibiting their formation, thereby reducing oxidative stress. Benefiting from significant advances in nanotechnology, a large number of nanomaterials with ROS-scavenging capabilities have been developed. ROS-scavenging nanomaterials can be divided into two categories: nanomaterials as carriers for delivering ROS-scavenging drugs, and nanomaterials themselves with ROS-scavenging activity. This study summarizes the current advances in ROS-scavenging nanomaterials for prevention and treatment of ARD, highlights the potential mechanisms of the nanomaterials used and discusses the challenges and prospects for their applications.

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The Hallmarks of Aging

Carlos López-Otín, Maria Blasco, Linda Partridge … (2014)

Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contributions to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging, with minimal side effects. Copyright © 2013 Elsevier Inc. All rights reserved.

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IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040.

K. Ogurtsova, J.D. da Rocha Fernandes, Y. Huang … (2017)

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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies, Dean Jones (2020)

'Reactive oxygen species' (ROS) is an umbrella term for an array of derivatives of molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the different ROS leads to molecular damage, denoted as 'oxidative distress'. Here we focus on ROS at physiological levels and their central role in redox signalling via different post-translational modifications, denoted as 'oxidative eustress'. Two species, hydrogen peroxide (H2O2) and the superoxide anion radical (O2·-), are key redox signalling agents generated under the control of growth factors and cytokines by more than 40 enzymes, prominently including NADPH oxidases and the mitochondrial electron transport chain. At the low physiological levels in the nanomolar range, H2O2 is the major agent signalling through specific protein targets, which engage in metabolic regulation and stress responses to support cellular adaptation to a changing environment and stress. In addition, several other reactive species are involved in redox signalling, for instance nitric oxide, hydrogen sulfide and oxidized lipids. Recent methodological advances permit the assessment of molecular interactions of specific ROS molecules with specific targets in redox signalling pathways. Accordingly, major advances have occurred in understanding the role of these oxidants in physiology and disease, including the nervous, cardiovascular and immune systems, skeletal muscle and metabolic regulation as well as ageing and cancer. In the past, unspecific elimination of ROS by use of low molecular mass antioxidant compounds was not successful in counteracting disease initiation and progression in clinical trials. However, controlling specific ROS-mediated signalling pathways by selective targeting offers a perspective for a future of more refined redox medicine. This includes enzymatic defence systems such as those controlled by the stress-response transcription factors NRF2 and nuclear factor-κB, the role of trace elements such as selenium, the use of redox drugs and the modulation of environmental factors collectively known as the exposome (for example, nutrition, lifestyle and irradiation).

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Author and article information

Contributors

Meng Wu: mengwu@tjh.tjmu.edu.cn

Jun Dai: jundai@tjh.tjmu.edu.cn

Shixuan Wang: shixuanwang@tjh.tjmu.edu.cn

Journal

Journal ID (nlm-ta): J Nanobiotechnology

Journal ID (iso-abbrev): J Nanobiotechnology

Title: Journal of Nanobiotechnology

Publisher: BioMed Central (London )

ISSN (Electronic): 1477-3155

Publication date (Electronic): 15 May 2024

Publication date PMC-release: 15 May 2024

Publication date Collection: 2024

Volume: 22

Electronic Location Identifier: 252

Affiliations

[1 ]GRID grid.33199.31, ISNI 0000 0004 0368 7223, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, , Huazhong University of Science and Technology, ; Wuhan, 430030 Hubei China

[2 ]National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, 430030 Hubei China

[3 ]GRID grid.419897.a, ISNI 0000 0004 0369 313X, Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, ; Wuhan, 430030 Hubei China

[4 ]Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, ( https://ror.org/03et85d35) Ningbo, 315800 China

Article

Publisher ID: 2501

DOI: 10.1186/s12951-024-02501-9

PMC ID: 11097501

PubMed ID: 38750509

SO-VID: 7567ab04-8661-4e50-bfa9-75278fa7f020

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 1 March 2024

Date accepted : 28 April 2024

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ScienceOpen disciplines: Biotechnology

Keywords: aging,age-related disease,nanomaterials,antioxidant,reactive oxygen species

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ScienceOpen disciplines: Biotechnology

Keywords: aging, age-related disease, nanomaterials, antioxidant, reactive oxygen species

Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases

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IEEE: COVID-19 related research

Most cited references 368

The Hallmarks of Aging

IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040.

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

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