Cervical cancer metabolic tumour volume (MTV) derived from [18F]-FDG PET/CT has a role in prognostication and therapy planning. There is no standard method of outlining MTV on [18F]-FDG PET/CT. The aim of this study was to assess the optimal method to outline primary cervical tumours on [18F]-FDG PET/CT using MRI-derived tumour volumes as the reference standard.
81 consecutive cervical cancer patients with pre-treatment staging MRI and [18F]-FDG PET/CT imaging were included. MRI volumes were compared with different PET segmentation methods. Method 1 measured MTVs at different SUV max thresholds ranging from 20 to 60% (MTV 20-MTV 60) with bladder masking and manual adjustment when required. Method 2 created an isocontour around the tumour prior to different SUV max thresholds being applied. Method 3 used an automated gradient method. Inter-observer agreement of MTV, following manual adjustment when required, was recorded.
For method 1, the MTV 25 and MTV 30 were closest to the MRI volumes for both readers (mean percentage change from MRI volume of 2.9% and 13.4% for MTV 25 and − 13.1% and − 2.0% for MTV 30 for readers 1 and 2). 70% of lesions required manual adjustment at MTV 25 compared with 45% at MTV 30. There was excellent inter-observer agreement between MTV 30 to MTV 60 (ICC ranged from 0.898–0.976 with narrow 95% confidence intervals (CIs)) and moderate agreement at lower thresholds (ICC estimates of 0.534 and 0.617, respectively for the MTV 20 and MTV 25 with wide 95% CIs). Bladder masking was performed in 86% of cases overall. For method 2, excellent correlation was demonstrated at MTV 25 and MTV 30 (mean % change from MRI volume of −3.9% and − 8.6% for MTV 25 and − 16.9% and 19% for MTV 30 for readers 1 and 2, respectively). This method also demonstrated excellent ICC across all thresholds with no manual adjustment. Method 3 demonstrated excellent ICC of 0.96 (95% CI 0.94–0.97) but had a mean percentage difference from the MRI volume of − 19.1 and − 18.2% for readers 1 and 2, respectively. 21% required manual adjustment for both readers.