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Abstract
To develop a new mucoadhesive drug carrier, poly(vinyl pyrrolidone) (PVP)/poly(acrylic
acid) (PAA) interpolymer complexes were prepared by the template polymerization of
acrylic acid using PVP as a template polymer. Fourier transform infrared results showed
that the interpolymer complexes were formed by hydrogen bonds between the carboxyl
groups of PAA and the carbonyl groups of PVP. The adhesive forces of the PVP/PAA interpolymer
complexes were higher than that of commercial Carbopol 971. Moreover, the adhesive
force and the release rate can be controlled by changing the mole ratios of PVP and
PAA. The release rates of ketoprofen from the PVP/PAA interpolymer complexes showed
pH-dependency, and were slower at lower pH. The release rate of ketoprofen from the
complex seemed to be mainly controlled by the dissolution rate of the complex above
a pK(a) of PAA (4.75) and by the diffusion rate below the pK(a). The prepared complex
appears to be an adequate carrier for the mucoadhesive drug delivery system.