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      Reducing Intrusive Memories of Childhood Trauma Using a Visuospatial Intervention: Case Study in Iceland

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          Abstract

          Background

          Additional interventions are needed for survivors of psychological trauma because of several barriers to and limitations of existing treatment options (eg, need to talk about the trauma in detail). Case studies are an important step in exploring the development of novel interventions, allowing detailed examination of individual responses to treatment over time. Here, we present a case study that aims to test a novel intervention designed to disrupt memory reconsolidation, taking a single-symptom approach by focusing on intrusive memories of a traumatic event.

          Objective

          This study aims to examine a novel brief cognitive intervention to reduce the number of intrusive memories of trauma in an Icelandic setting and to extend previous studies by examining long-term effects for up to 3 months. The intervention was guided by a clinical psychologist and comprised a brief memory reminder, followed by Tetris gameplay with mental rotation, targeting one memory at a time in each session.

          Methods

          This was a single case study in Iceland with a woman in her 50s (drawn from an epidemiological study of trauma) with subthreshold posttraumatic stress disorder and a diagnosis of obsessive-compulsive disorder and social anxiety disorder. The participant had four different intrusive memories from a traumatic event that happened in her childhood. The primary outcome was the change in the number of intrusive memories from baseline to intervention phase and to follow-ups. The number of intrusions was monitored in a daily diary for 4 weeks preintervention, 8 weeks during the intervention, and 1 week at 1-month and 3-month follow-ups. Intrusions were targeted one by one over six intervention sessions, creating four repetitions of an AB design (ie, length of baseline A and intervention phase B varied for each memory). We examined changes in both the total number of intrusions (summed across all four memories) and individually for each memory. In addition, we explored whether having fewer intrusive memories would have an impact on functioning, posttraumatic stress, and depression or anxiety symptoms.

          Results

          The total number of intrusions per week was 12.6 at baseline, 6.1 at the intervention phase (52% reduction from baseline), 3.0 at the 1-month follow-up (76% reduction), and 1.0 at the 3-month follow-up (92% reduction). Reductions in the symptoms of posttraumatic stress and depression were observed postintervention. Sleep, concentration, stress, and functioning improved. The participant considered the gameplay intervention acceptable and helpful in that she found that the memories disappeared while she was playing.

          Conclusions

          This guided brief cognitive intervention reduced the number of intrusive memories over the intervention phase and follow-ups. The brief memory reminder was well tolerated, removing the need to discuss trauma in detail. The next steps require an extension to more cases and exploring remote delivery of the intervention.

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          Most cited references49

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          Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.

          Research electronic data capture (REDCap) is a novel workflow methodology and software solution designed for rapid development and deployment of electronic data capture tools to support clinical and translational research. We present: (1) a brief description of the REDCap metadata-driven software toolset; (2) detail concerning the capture and use of study-related metadata from scientific research teams; (3) measures of impact for REDCap; (4) details concerning a consortium network of domestic and international institutions collaborating on the project; and (5) strengths and limitations of the REDCap system. REDCap is currently supporting 286 translational research projects in a growing collaborative network including 27 active partner institutions.
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            A brief measure for assessing generalized anxiety disorder: the GAD-7.

            Generalized anxiety disorder (GAD) is one of the most common mental disorders; however, there is no brief clinical measure for assessing GAD. The objective of this study was to develop a brief self-report scale to identify probable cases of GAD and evaluate its reliability and validity. A criterion-standard study was performed in 15 primary care clinics in the United States from November 2004 through June 2005. Of a total of 2740 adult patients completing a study questionnaire, 965 patients had a telephone interview with a mental health professional within 1 week. For criterion and construct validity, GAD self-report scale diagnoses were compared with independent diagnoses made by mental health professionals; functional status measures; disability days; and health care use. A 7-item anxiety scale (GAD-7) had good reliability, as well as criterion, construct, factorial, and procedural validity. A cut point was identified that optimized sensitivity (89%) and specificity (82%). Increasing scores on the scale were strongly associated with multiple domains of functional impairment (all 6 Medical Outcomes Study Short-Form General Health Survey scales and disability days). Although GAD and depression symptoms frequently co-occurred, factor analysis confirmed them as distinct dimensions. Moreover, GAD and depression symptoms had differing but independent effects on functional impairment and disability. There was good agreement between self-report and interviewer-administered versions of the scale. The GAD-7 is a valid and efficient tool for screening for GAD and assessing its severity in clinical practice and research.
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              The PHQ-9: validity of a brief depression severity measure.

              While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity. The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as "0" (not at all) to "3" (nearly every day). The PHQ-9 was completed by 6,000 patients in 8 primary care clinics and 7 obstetrics-gynecology clinics. Construct validity was assessed using the 20-item Short-Form General Health Survey, self-reported sick days and clinic visits, and symptom-related difficulty. Criterion validity was assessed against an independent structured mental health professional (MHP) interview in a sample of 580 patients. As PHQ-9 depression severity increased, there was a substantial decrease in functional status on all 6 SF-20 subscales. Also, symptom-related difficulty, sick days, and health care utilization increased. Using the MHP reinterview as the criterion standard, a PHQ-9 score > or =10 had a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 represented mild, moderate, moderately severe, and severe depression, respectively. Results were similar in the primary care and obstetrics-gynecology samples. In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity. These characteristics plus its brevity make the PHQ-9 a useful clinical and research tool.
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                Author and article information

                Contributors
                Journal
                JMIR Form Res
                JMIR Form Res
                JFR
                JMIR Formative Research
                JMIR Publications (Toronto, Canada )
                2561-326X
                November 2021
                4 November 2021
                : 5
                : 11
                : e29873
                Affiliations
                [1 ] Department of Psychology University of Iceland Reykjavik Iceland
                [2 ] Department of Psychology Uppsala University Uppsala Sweden
                [3 ] Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
                [4 ] Swedish Collegium for Advanced Study Uppsala Sweden
                [5 ] Centre of Public Health Sciences University of Iceland Reykjavik Iceland
                [6 ] Faculty of Medicine University of Iceland Reykjavik Iceland
                [7 ] Landspitali - The National University Hospital of Iceland Reykjavik Iceland
                [8 ] Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
                [9 ] Department of Epidemiology Harvard TH Chan School of Public Health Boston, MA United States
                Author notes
                Corresponding Author: Kristjana Thorarinsdottir kth35@ 123456hi.is
                Author information
                https://orcid.org/0000-0002-9939-1333
                https://orcid.org/0000-0001-7319-3112
                https://orcid.org/0000-0002-3598-0526
                https://orcid.org/0000-0002-4417-2029
                https://orcid.org/0000-0003-2060-5288
                https://orcid.org/0000-0003-0148-7247
                https://orcid.org/0000-0002-4253-1059
                https://orcid.org/0000-0003-0637-8912
                https://orcid.org/0000-0002-4145-7723
                https://orcid.org/0000-0001-5382-946X
                https://orcid.org/0000-0003-3775-9611
                https://orcid.org/0000-0001-8284-9371
                https://orcid.org/0000-0003-0307-2512
                Article
                v5i11e29873
                10.2196/29873
                8603162
                34734830
                7499bd22-6a0b-4337-89d7-509fb6778ac2
                ©Kristjana Thorarinsdottir, Emily A Holmes, Johann Hardarson, Unnur Hedinsdottir, Marie Kanstrup, Laura Singh, Arna Hauksdottir, Thorhildur Halldorsdottir, Berglind Gudmundsdottir, Unnur Valdimarsdottir, Edda Bjork Thordardottir, Beau Gamble, Andri Bjornsson. Originally published in JMIR Formative Research (https://formative.jmir.org), 04.11.2021.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Formative Research, is properly cited. The complete bibliographic information, a link to the original publication on https://formative.jmir.org, as well as this copyright and license information must be included.

                History
                : 23 April 2021
                : 20 May 2021
                : 11 June 2021
                : 5 July 2021
                Categories
                Original Paper
                Original Paper

                psychological trauma,intrusive memories,case report,visuospatial interference task,tetris gameplay,mental imagery,mobile phone

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