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      Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

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          Abstract

          This 2017 review discusses developments in elemental mass spectrometry, atomic absorption, emission and fluorescence, XRF and LIBS, as applied to the analysis of specimens of clinical interest, foods and beverages. Sample preparation procedures and quality assurance are also included.

          Abstract

          This review covers publications from the second half of 2015 to the middle of 2016. Techniques and applications relevant to clinical and biological materials, foods and beverages are discussed in the text, presenting the key aspects of the work referenced, while the tables provide a summary of the publications considered. An important development seen within the year is the way in which nanomaterials feature in many of the topics considered in this review. With nanoparticles used as antibacterial agents (containing Ag) in medical devices and in food packaging materials, as vehicles for delivering drugs to tissues and cells and in horticulture, methods for analysis of various sample types that may contain nanomaterials have been developed. Properties of nanoparticles and nanotubes were also exploited for analyte preconcentration in measurement procedures. The implications of recent regulations relating to concentrations of trace elements in infant foods, arsenic in rice and methyl mercury in seafoods were evident, with methods specifically developed with these challenges in mind. Emerging topics to look out for in coming years include applications using triple quadrupole ICP-MS and portable XRF spectrometers.

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          Most cited references176

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          Biomarkers of Nutrition for Development (BOND)-Zinc Review.

          Zinc is required for multiple metabolic processes as a structural, regulatory, or catalytic ion. Cellular, tissue, and whole-body zinc homeostasis is tightly controlled to sustain metabolic functions over a wide range of zinc intakes, making it difficult to assess zinc insufficiency or excess. The BOND (Biomarkers of Nutrition for Development) Zinc Expert Panel recommends 3 measurements for estimating zinc status: dietary zinc intake, plasma zinc concentration (PZC), and height-for-age of growing infants and children. The amount of dietary zinc potentially available for absorption, which requires an estimate of dietary zinc and phytate, can be used to identify individuals and populations at risk of zinc deficiency. PZCs respond to severe dietary zinc restriction and to zinc supplementation; they also change with shifts in whole-body zinc balance and clinical signs of zinc deficiency. PZC cutoffs are available to identify individuals and populations at risk of zinc deficiency. However, there are limitations in using the PZC to assess zinc status. PZCs respond less to additional zinc provided in food than to a supplement administered between meals, there is considerable interindividual variability in PZCs with changes in dietary zinc, and PZCs are influenced by recent meal consumption, the time of day, inflammation, and certain drugs and hormones. Insufficient data are available on hair, urinary, nail, and blood cell zinc responses to changes in dietary zinc to recommend these biomarkers for assessing zinc status. Of the potential functional indicators of zinc, growth is the only one that is recommended. Because pharmacologic zinc doses are unlikely to enhance growth, a growth response to supplemental zinc is interpreted as indicating pre-existing zinc deficiency. Other functional indicators reviewed but not recommended for assessing zinc nutrition in clinical or field settings because of insufficient information are the activity or amounts of zinc-dependent enzymes and proteins and biomarkers of oxidative stress, inflammation, or DNA damage.
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            Mass spectrometry imaging for plant biology: a review

            Mass spectrometry imaging (MSI) is a developing technique to measure the spatio-temporal distribution of many biomolecules in tissues. Over the preceding decade, MSI has been adopted by plant biologists and applied in a broad range of areas, including primary metabolism, natural products, plant defense, plant responses to abiotic and biotic stress, plant lipids and the developing field of spatial metabolomics. This review covers recent advances in plant-based MSI, general aspects of instrumentation, analytical approaches, sample preparation and the current trends in respective plant research.
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              Surface Charge Controls the Suborgan Biodistributions of Gold Nanoparticles.

              Surface chemistry plays a deciding role in nanoparticle biodistribution, yet very little is known about how surface chemistry influences the suborgan distributions of nanomaterials. Here, using quantitative imaging based on laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), we demonstrate that surface charge dictates the suborgan distributions of nanoparticles in the kidney, liver, and spleen of mice intravenously injected with functionalized gold nanoparticles. Images of the kidney show that positively charged nanoparticles accumulate extensively in the glomeruli, the initial stage in filtering for the nephron, suggesting that these nanoparticles may be filtered by the kidney at a different rate than the neutral or negatively charged nanoparticles. We find that positively and negatively charged nanoparticles accumulate extensively in the red pulp of the spleen. In contrast, uncharged nanoparticles accumulate in the white pulp and marginal zone of the spleen to a greater extent than the positively or negatively charged nanoparticles. Moreover, these uncharged nanoparticles are also more likely to be found associated with Kupffer cells in the liver. Positively charged nanoparticles accumulate extensively in liver hepatocytes, whereas negatively charged nanoparticles show a broader distribution in the liver. Together these observations suggest that neutral nanoparticles having 2 nm cores may interact with the immune system to a greater extent than charged nanoparticles, highlighting the value of determining the suborgan distributions of nanomaterials for delivery and imaging applications.
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                Author and article information

                Journal
                JASPE2
                Journal of Analytical Atomic Spectrometry
                J. Anal. At. Spectrom.
                Royal Society of Chemistry (RSC)
                0267-9477
                1364-5544
                2017
                2017
                : 32
                : 3
                : 432-476
                Affiliations
                [1 ]Supra-regional Assay Service
                [2 ]Trace Element Laboratory
                [3 ]Royal Surrey County Hospital
                [4 ]Guildford
                [5 ]UK
                [6 ]Trace Elements Laboratory
                [7 ]Department of Clinical Biochemistry
                [8 ]Sandwell General Hospital
                [9 ]West Bromwich
                [10 ]The Australian Wine Research Institute
                [11 ]Glen Osmond
                [12 ]Australia
                [13 ]LGC
                [14 ]Istituto Superiore di Sanitá
                [15 ]00161 Roma
                [16 ]Italy
                [17 ]Science Directorate
                [18 ]HSE
                [19 ]Buxton
                Article
                10.1039/C7JA90005H
                748ea5d5-64a6-4827-94a2-070fddb7fc4c
                © 2017
                History

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