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      Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

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      American Association for the Advancement of Science (AAAS)

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          Abstract

          Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months. To address this need, we introduce the Neuropixels 2.0 probe together with newly designed analysis algorithms. The probe has more than 5000 sites and is miniaturized to facilitate chronic implants in small mammals and recording during unrestrained behavior. High-quality recordings over long time scales were reliably obtained in mice and rats in six laboratories. Improved site density and arrangement combined with newly created data processing methods enable automatic post hoc correction for brain movements, allowing recording from the same neurons for more than 2 months. These probes and algorithms enable stable recordings from thousands of sites during free behavior, even in small animals such as mice.

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          A statistical approach to some basic mine valuation problems on the Witwatersrand

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            The tetrode: a new technique for multi-unit extracellular recording

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              The Argo: A high channel count recording system for neural recording in vivo

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                Journal
                Science
                Science
                American Association for the Advancement of Science (AAAS)
                0036-8075
                1095-9203
                April 15 2021
                April 16 2021
                April 16 2021
                April 15 2021
                : 372
                : 6539
                : eabf4588
                Affiliations
                [1 ]UCL Institute of Ophthalmology, University College London, London, UK.
                [2 ]Department of Biological Structure, University of Washington, Seattle, WA, USA.
                [3 ]Neuroelectronics Research Flanders, Leuven, Belgium.
                [4 ]Sainsbury Wellcome Centre, University College London, London, UK.
                [5 ]Centre for Systems Neuroscience and Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK.
                [6 ]UCL Queen Square Institute of Neurology, University College London, London, UK.
                [7 ]Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
                [8 ]Wolfson Institute for Biomedical Research, University College London, London, UK.
                [9 ]Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
                [10 ]IMEC, Leuven, Belgium.
                [11 ]Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.
                [12 ]Brain and Cognition, KU Leuven, Leuven, Belgium.
                [13 ]ATLAS Neuroengineering, Leuven, Belgium.
                [14 ]Micro- and Nanosystems, KU Leuven, Leuven, Belgium.
                [15 ]Champalimaud Centre for the Unknown, Lisbon, Portugal.
                Article
                10.1126/science.abf4588
                33859006
                73af5cdd-a352-4564-934b-6441f1acc7a0
                © 2021

                https://www.sciencemag.org/about/science-licenses-journal-article-reuse

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