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      Actividad bactericida de extractos acuosos de Lippia alba (Mill.) N.E. Brown contra Helicobacter pylori Translated title: Antibacterial activity of aqueous extracts of Lippia alba (Mill.) N.E. Brown against Helicobacter pylori

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          Abstract

          Lippia alba (Mill) N.E. Brown es una planta medicinal conocida en Colombia como "prontoalivio" y que se emplea para el tratamiento de múltiples dolencias gastrointestinales. El aceite esencial, los extractos acuosos y alcohólicos obtenidos de la planta han mostrado poder antibacteriano, antiviral, antiparasitario y antimicótico. En el presente estudio, se determinó el efecto antibacteriano in vitro del extracto acuoso de las hojas de Lippia alba contra tres aislados de Helicobacter pylori. Se requieren estudios adicionales que permitan establecer el potencial uso clínico del extracto acuoso en combinación con los tratamientos antibióticos.

          Translated abstract

          Lippia alba (Mill) N.E. Brown is a medicinal plant known in Colombia as "prontoalivio" (= fast relief). It is used for the treatment of multiple gastro-intestinal ailments. The essential oil, the aqueous and alcoholic extracts obtained from the plant have demonstrated antibacterial, antiviral, anti-parasitic and antimycotic power. In the current in vitro study of the aqueous extracts from Lippia alba leaves against three isolated Helicobacter pylori cultures, it was determined that there was an antibacterial effect. There are needed additional studies that allow to establish the potential clinical use of the aqueous extracts in combination with the antibiotic treatment.

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          Most cited references52

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          H pylori antibiotic resistance: prevalence, importance, and advances in testing.

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            Schistosomes: Liver Flukes and Helicobacter pylori

            (1994)
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              Multitarget therapy--the future of treatment for more than just functional dyspepsia.

              Since many years the concept of classical phytotherapy using herbal drug combinations with superior efficacy and lesser side effects in comparison with single isolated constituents of plant extracts has been repeatedly assessed clinically as well as pharmacologically. For this as multitarget therapy defined treatment lot of examples are presented. The exact mechanisms of action underlying these synergy effects is unknown. It could be explained by a multitarget action of compounds on a molecular level or partly by an improved resorption rate and a change of pharmacokinetic. Progress in the field of drug synergy research may lend with standardized plant extracts a new legitimacy and may open the chance to use extract combinations for the treatment of diseases which previously have been reserved for chemotherapeutics only.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                rcg
                Revista Colombiana de Gastroenterologia
                Rev Col Gastroenterol
                Asociación Colombiana de Gastroenterología (Bogotá )
                0120-9957
                June 2011
                : 26
                : 2
                : 82-87
                Affiliations
                [1 ] Universidad Nacional de Colombia Colombia
                [2 ] Universidad Nacional de Colombia Colombia
                [3 ] Colegio Mayor de Cundinamarca Colombia
                [4 ] Universidad Nacional de Colombia Colombia
                Article
                S0120-99572011000200002
                739c5aa9-40de-4cf4-8265-e2fd592ee0c5

                http://creativecommons.org/licenses/by/4.0/

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                SciELO Colombia

                Self URI (journal page): http://www.scielo.org.co/scielo.php?script=sci_serial&pid=0120-9957&lng=en
                Categories
                GASTROENTEROLOGY & HEPATOLOGY

                Gastroenterology & Hepatology
                Helicobacter pylori,Lippia alba,inhibition,antibacterial activity,inhibición,actividad bactericida

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