Vulvar aphthous ulcer in an adolescent after Pfizer-BioNTech (BNT162b2) COVID-19 vaccination

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Abstract

Background

Vulvar aphthous ulcers are a rare type of genital lesion most common in non-sexually active adolescents. Vulvar aphthous ulcers are typically associated with viral infections. To date, there have been several cases reported in patients infected with COVID-19. Vulvar aphthous ulcers have not been previously reported in the literature following vaccination.

Case

We present the case of a 16-year-old adolescent who developed vulvar aphthous ulceration following Pfizer-BioNTech (BNT162b2) vaccination.

Summary and Conclusion

Through an extensive literature search, we found no previous reports of vulvar aphthous ulcer following vaccination. Our case highlights a potential novel side effect of Pfizer-BioNTech COVID-19 vaccination and a new etiology for vulvar aphthous ulcers. This case suggests that vulvar aphthous ulcers may be associated with COVID-19 vaccination through a yet undetermined mechanism that requires further investigation.

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Author and article information

Journal

Journal ID (nlm-ta): J Pediatr Adolesc Gynecol

Journal ID (iso-abbrev): J Pediatr Adolesc Gynecol

Title: Journal of Pediatric and Adolescent Gynecology

Publisher: Published by Elsevier Inc. on behalf of North American Society for Pediatric and Adolescent Gynecology.

ISSN (Print): 1083-3188

ISSN (Electronic): 1873-4332

Publication date PMC-release: 25 October 2021

Publication date (Electronic): 25 October 2021

Affiliations

[1 ]Medical School, University of Minnesota, Minneapolis, MN, USA

[2 ]Department of Pediatric and Adolescent Gynecology, Children's Minnesota, Minneapolis, MN, USA

Author notes

[* ]Address correspondence to: Katherine O'Flynn O'Brien, MD, Children's Minnesota Pediatric Adolescent Gynecology, 2530 Chicago Ave S STE 390, Minneapolis, MN 55404. Phone: 651-220-5999.

Article

Publisher Item ID: S1083-3188(21)00304-1

DOI: 10.1016/j.jpag.2021.10.005

PMC ID: 8542512

PubMed ID: 34706274

SO-VID: 737889fc-b3ce-4a5a-9204-04696ffaafd2

License:

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

History

Date received : 17 July 2021

Date revision received : 5 October 2021

Date accepted : 11 October 2021

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