For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
Inviting an author to review:
Endogenous endothelin stimulates cardiac sympathetic afferents during ischaemia.
Find an author and click ‘Invite to review selected article’ near their name.
Search for authorsSearch for similar articles
25
views
Article has an altmetric score of 4
26
references
 Top references
cited by
84
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      304
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensitivity, with great promise for clinical translation and quantitative single-cell tracking. Here we report the first MPI cell tracking study, showing 200-cell detection in vitro and in vivo monitoring of human neural graft clearance over 87 days in rat brain.

          Related collections

          Most cited references26

          • Record: found
          • Abstract: found
          • Article: not found

          Tomographic imaging using the nonlinear response of magnetic particles.

          Bernhard Gleich, Jürgen Weizenecker (2005)
          The use of contrast agents and tracers in medical imaging has a long history. They provide important information for diagnosis and therapy, but for some desired applications, a higher resolution is required than can be obtained using the currently available medical imaging techniques. Consider, for example, the use of magnetic tracers in magnetic resonance imaging: detection thresholds for in vitro and in vivo imaging are such that the background signal from the host tissue is a crucial limiting factor. A sensitive method for detecting the magnetic particles directly is to measure their magnetic fields using relaxometry; but this approach has the drawback that the inverse problem (associated with transforming the data into a spatial image) is ill posed and therefore yields low spatial resolution. Here we present a method for obtaining a high-resolution image of such tracers that takes advantage of the nonlinear magnetization curve of small magnetic particles. Initial 'phantom' experiments are reported that demonstrate the feasibility of the imaging method. The resolution that we achieve is already well below 1 mm. We evaluate the prospects for further improvement, and show that the method has the potential to be developed into an imaging method characterized by both high spatial resolution as well as high sensitivity.
          Article 0 comments Cited 390 times – based on 0 reviews     Review now
          Article has an altmetric score of 28
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy.

            Jack van Loon, Otto C. Boerman, T Scheenen … (2005)
            The success of cellular therapies will depend in part on accurate delivery of cells to target organs. In dendritic cell therapy, in particular, delivery and subsequent migration of cells to regional lymph nodes is essential for effective stimulation of the immune system. We show here that in vivo magnetic resonance tracking of magnetically labeled cells is feasible in humans for detecting very low numbers of dendritic cells in conjunction with detailed anatomical information. Autologous dendritic cells were labeled with a clinical superparamagnetic iron oxide formulation or (111)In-oxine and were co-injected intranodally in melanoma patients under ultrasound guidance. In contrast to scintigraphic imaging, magnetic resonance imaging (MRI) allowed assessment of the accuracy of dendritic cell delivery and of inter- and intra-nodal cell migration patterns. MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans.
            Article 0 comments Cited 162 times – based on 0 reviews     Review now
            Article has an altmetric score of 6
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model.

              Claes Wahlestedt, Lars Björklund, Iris Yin Ching Chen … (2002)
              Although implantation of fetal dopamine (DA) neurons can reduce parkinsonism in patients, current methods are rudimentary, and a reliable donor cell source is lacking. We show that transplanting low doses of undifferentiated mouse embryonic stem (ES) cells into the rat striatum results in a proliferation of ES cells into fully differentiated DA neurons. ES cell-derived DA neurons caused gradual and sustained behavioral restoration of DA-mediated motor asymmetry. Behavioral recovery paralleled in vivo positron emission tomography and functional magnetic resonance imaging data demonstrating DA-mediated hemodynamic changes in the striatum and associated brain circuitry. These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease.
              Article 0 comments Cited 151 times – based on 0 reviews     Review now
              Article has an altmetric score of 60
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Sci Rep
                Journal ID (iso-abbrev): Sci Rep
                Title: Scientific Reports
                Publisher: Nature Publishing Group
                ISSN (Electronic): 2045-2322
                Publication date (Electronic): 11 September 2015
                Publication date Collection: 2015
                Volume: 5
                Electronic Location Identifier: 14055
                Affiliations
                [1 ]Department of Bioengineering, University of California at Berkeley , Berkeley, CA 94720, USA
                [2 ]Department of Chemical and Biomolecular Engineering, University of California at Berkeley , Berkeley, CA 94720, USA
                [3 ]Department of Molecular and Cell Biology, University of California at Berkeley , Berkeley, CA 94720, USA
                [4 ]Magnetic Insight, Inc. , Newark, CA 94560, USA
                [5 ]Department of Electrical Engineering and Computer Science, University of California at Berkeley , Berkeley, CA 94720, USA
                Author notes
                Article
                Publisher Item ID: srep14055
                DOI: 10.1038/srep14055
                PMC ID: 4566119
                PubMed ID: 26358296
                SO-VID: 731e9a31-6baa-479d-b299-e567084b2059
                Copyright © Copyright © 2015, Macmillan Publishers Limited
                License:

                This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

                History
                Date received : 24 March 2015
                Date accepted : 12 August 2015
                Categories
                Subject: Article

                ScienceOpen disciplines: Uncategorized
                Data availability:
                ScienceOpen disciplines: Uncategorized

                Comments

                Comment on this article

                scite_
                0
                0
                0
                0
                Smart Citations
                0
                0
                0
                0
                Citing PublicationsSupportingMentioningContrasting
                View Citations

                See how this article has been cited at scite.ai

                scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

                Similar content304

                See all similar

                Cited by81

                See all cited by

                Most referenced authors473

                See all reference authors