Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis.

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Abstract

A high level of galectin-3-binding protein (G3BP) appears to distinguish circulating cell-derived microparticles in systemic lupus erythematosus (SLE). The aim of this study is to characterize the population of G3BP-positive microparticles from SLE patients compared to healthy controls, explore putative clinical correlates, and examine if G3BP is present in immune complex deposits in kidney biopsies from patients with lupus nephritis.

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Journal

Journal ID (iso-abbrev): Lupus

Title: Lupus

Publisher: SAGE Publications

ISSN (Electronic): 1477-0962

ISSN (Print): 0961-2033

Publication date (Electronic): Oct 2015

Volume: 24

Issue: 11

Affiliations

[1 ] Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark Department of Infectious Disease and Rheumatology, University Hospital Rigshospitalet, Copenhagen, Denmark christoffertandrupnielsen@gmail.com.

[2 ] Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark.

[3 ] RNA and Molecular Pathology Research Group, University of Tromsø, Tromsø, Norway.

[4 ] Department of Rheumatology, University Hospital of Lund, Lund, Sweden.

[5 ] Department of Infectious Disease and Rheumatology, University Hospital Rigshospitalet, Copenhagen, Denmark.

Article

Publisher Item ID: 0961203315580146

DOI: 10.1177/0961203315580146

PubMed ID: 25837289

SO-VID: 73172c93-3a99-4ad0-96de-ac45d47df878

History

Keywords: Galectin-3-binding protein,Mac-2-binding protein,electron dense deposits,immune complexes,lupus nephritis,microparticles,systemic lupus erythematosus

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Keywords: Galectin-3-binding protein, Mac-2-binding protein, electron dense deposits, immune complexes, lupus nephritis, microparticles, systemic lupus erythematosus

Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis.

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Abstract

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Journal of Circulating Biomarkers

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