Milk Fat Globule Membrane Inhibits NLRP3 Inflammasome Activation and Enhances Intestinal Barrier Function in a Rat Model of Short Bowel.

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Abstract

The milk fat globule membrane (MFGM) contains various bioactive components which have been shown to maintain gut barrier integrity. This study aimed to evaluate the protective effects of MFGM on intestinal barrier function and its possible mechanisms in a rat model of short bowel syndrome (SBS).

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Author and article information

Journal

Journal ID (iso-abbrev): JPEN J Parenter Enteral Nutr

Title: JPEN. Journal of parenteral and enteral nutrition

Publisher: Wiley

ISSN (Electronic): 1941-2444

ISSN (Print): 0148-6071

Publication date (Electronic): July 2019

Volume: 43

Issue: 5

Affiliations

[1 ] Department of Clinical Nutrition, Xin Hua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.

[2 ] Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.

[3 ] Mead Johnson Pediatric Nutrition Institute, Nijmegen, the Netherlands.

[4 ] Department of Pediatric Surgery, Xin Hua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Article

DOI: 10.1002/jpen.1435

PubMed ID: 30144105

SO-VID: 729f8418-0461-4598-9203-d24198fc834c

History

Keywords: short bowel syndrome,milk fat globule membrane,intestinal barrier function,NLRP3 inflammasome

Data availability:

Keywords: short bowel syndrome, milk fat globule membrane, intestinal barrier function, NLRP3 inflammasome

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