A Proline Residue in the α-Helical Rod Domain of Type I Keratin 16 Destabilizes Keratin Heterotetramers

Over the past five years, the structures of more than 20 proteins containing coiled-coil domains have been solved to high resolution. This has provided many new insights into the structure of coiled coils, their discontinuities, their relationship with other helical bundles and the problems connected with their prediction from protein sequences.