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      The contribution of wheat to human diet and health

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          Abstract

          Wheat is the most important staple crop in temperate zones and is in increasing demand in countries undergoing urbanization and industrialization. In addition to being a major source of starch and energy, wheat also provides substantial amounts of a number of components which are essential or beneficial for health, notably protein, vitamins (notably B vitamins), dietary fiber, and phytochemicals. Of these, wheat is a particularly important source of dietary fiber, with bread alone providing 20% of the daily intake in the UK, and well‐established relationships between the consumption of cereal dietary fiber and reduced risk of cardio‐vascular disease, type 2 diabetes, and forms of cancer (notably colo‐rectal cancer). Wheat shows high variability in the contents and compositions of beneficial components, with some (including dietary fiber) showing high heritability. Hence, plant breeders should be able to select for enhanced health benefits in addition to increased crop yield.

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          Most cited references85

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          Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides.

          Resistant starch (RS) is starch and products of its small intestinal digestion that enter the large bowel. It occurs for various reasons including chemical structure, cooking of food, chemical modification, and food mastication. Human colonic bacteria ferment RS and nonstarch polysaccharides (NSP; major components of dietary fiber) to short-chain fatty acids (SCFA), mainly acetate, propionate, and butyrate. SCFA stimulate colonic blood flow and fluid and electrolyte uptake. Butyrate is a preferred substrate for colonocytes and appears to promote a normal phenotype in these cells. Fermentation of some RS types favors butyrate production. Measurement of colonic fermentation in humans is difficult, and indirect measures (e.g., fecal samples) or animal models have been used. Of the latter, rodents appear to be of limited value, and pigs or dogs are preferable. RS is less effective than NSP in stool bulking, but epidemiological data suggest that it is more protective against colorectal cancer, possibly via butyrate. RS is a prebiotic, but knowledge of its other interactions with the microflora is limited. The contribution of RS to fermentation and colonic physiology seems to be greater than that of NSP. However, the lack of a generally accepted analytical procedure that accommodates the major influences on RS means this is yet to be established.
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            Immune recognition. A new receptor for beta-glucans.

            The carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on macrophages and other white blood cells and activating them. Although beta-glucans are known to bind to receptors, such as complement receptor 3 (ref. 1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans.
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              Resistant starch: promise for improving human health.

              Ongoing research to develop digestion-resistant starch for human health promotion integrates the disciplines of starch chemistry, agronomy, analytical chemistry, food science, nutrition, pathology, and microbiology. The objectives of this research include identifying components of starch structure that confer digestion resistance, developing novel plants and starches, and modifying foods to incorporate these starches. Furthermore, recent and ongoing studies address the impact of digestion-resistant starches on the prevention and control of chronic human diseases, including diabetes, colon cancer, and obesity. This review provides a transdisciplinary overview of this field, including a description of types of resistant starches; factors in plants that affect digestion resistance; methods for starch analysis; challenges in developing food products with resistant starches; mammalian intestinal and gut bacterial metabolism; potential effects on gut microbiota; and impacts and mechanisms for the prevention and control of colon cancer, diabetes, and obesity. Although this has been an active area of research and considerable progress has been made, many questions regarding how to best use digestion-resistant starches in human diets for disease prevention must be answered before the full potential of resistant starches can be realized.
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                Author and article information

                Journal
                Food Energy Secur
                Food Energy Secur
                10.1002/(ISSN)2048-3694
                FES3
                Food and Energy Security
                John Wiley and Sons Inc. (Hoboken )
                2048-3694
                14 August 2015
                October 2015
                : 4
                : 3 ( doiID: 10.1002/fes3.2015.4.issue-3 )
                : 178-202
                Affiliations
                [ 1 ]Rothamsted Research Harpenden Hertfordshire AL5 2JQUK
                [ 2 ]University of Reading Whiteknights Reading Berkshire RG6 6AHUK
                Author notes
                [*] [* ] Correspondence

                Peter R. Shewry, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK. Tel: +44 (0) 1582 763133; Fax: +44 (0) 1582 763010; E‐mail: peter.shewry@ 123456rothamsted.ac.uk

                Article
                FES364
                10.1002/fes3.64
                4998136
                27610232
                720c6f62-1338-4d4e-a0a4-eb550675d4d9
                © 2015 The Authors. Food and Energy Security published by John Wiley & Sons Ltd. and the Association of Applied Biologists.

                This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 11 June 2015
                : 10 July 2015
                Page count
                Pages: 25
                Funding
                Funded by: CGIAR and the CGIAR WHEAT programme
                Award ID: A403 1.09.47
                Funded by: Biotechnological and Biological Sciences Research Council (BBSRC) of the UK
                Categories
                Review
                Reviews
                Custom metadata
                2.0
                fes364
                October 2015
                Converter:WILEY_ML3GV2_TO_NLMPMC version:4.9.4 mode:remove_FC converted:04.08.2016

                diet and health,dietary fiber,grain composition,phytochemicals,wheatwheat

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