Sandy Hwang Fang:
ORCID: https://orcid.org/0000-0002-9097-6968
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole:
SupervisionRole: ValidationRole: VisualizationRole: Writing – original draftRole:
Writing – review & editing
Mihaela Plesa: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: Writing – original draftRole: Writing – review & editing
Evie H. Carchman: Role: Data curationRole: InvestigationRole: Project administrationRole: ResourcesRole:
SupervisionRole: ValidationRole: Writing – review & editing
Nicole A. Cowell: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: ValidationRole: Writing – original draftRole:
Writing – review & editing
Emily Staudt: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole:
Writing – review & editing
Kyleigh Ann Twaroski: Role: Data curationRole: InvestigationRole: Project administrationRole: ResourcesRole:
SupervisionRole: Writing – review & editing
Ulrike K. Buchwald:
ORCID: https://orcid.org/0000-0002-6671-0115
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: Writing – review & editing
Cornelia L. Trimble: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Writing – review & editing
Diane M. Harper: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLOS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
15
December
2023
Publication date Collection: 2023
Volume: 18
Issue: 12
Electronic Location Identifier: e0295647
Affiliations
[1
]
Department of Surgery, Oregon Health & Science University, Portland, Oregon, United
States of America
[2
]
Frantz Medical Development, Ltd, Mentor, Ohio, United States of America
[3
]
Department of Surgery, University of Wisconsin School of Medicine, Madison, Wisconsin,
United States of America
[4
]
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland,
United States of America
[5
]
Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins
University School of Medicine, Baltimore, Maryland, United States of America
[6
]
Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine,
Baltimore, Maryland, United States of America
University of Michigan, UNITED STATES
Author notes
Competing Interests: The competing interest exists in the fact that Mihaela Plesa became the Director of
Research at Frantz Viral Therapeutics when she left Johns Hopkins Hospital. Please
note that we had already written the protocol, obtained FDA and IRB approval, and
started the study prior to Ms. Plesa leaving Hopkins to join Frantz Viral Therapeutics.
This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-23-09503
DOI: 10.1371/journal.pone.0295647
PMC ID: 10723659
PubMed ID: 38100463
SO-VID: 71f53e87-468f-470b-8ac4-e4bfbd3c0a84
Copyright © © 2023 Fang et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
Frantz Viral Therapeutics
Award Recipient
:
ORCID: https://orcid.org/0000-0002-9097-6968
Sandy Hwang Fang
Funded by:
Frantz Viral Therapeutics, LLC (FVT)
Award Recipient
:
Cornelia L. Trimble
The first author and principal investigator received funding for salary and research
support, from Frantz Viral Therapeutics. Frantz Viral Therapeutics, LLC designed,
formulated, and supplied the artesunate suppositories, which they provided free of
charge, and provided partial financial support for study management and specimen processing.
Dr. Trimble's institution reports grants from Frantz Viral Therapeutics, LLC (FVT),
for the conduct of the study. She is on the Scientific Advisory Board for FVT. Ms.
Plesa reports personal fees from Frantz Viral Therapeutics, LLC during the conduct
of the study. She works full-time as Director of Research Programs for FVT. Ulrike
K Buchwald is an employee of Merck Sharp & Dohme LLC., a subsidiary of Merck & Co.,
Inc., Rahway, NJ, USA and may own stock and/or stock options in Merck & Co., Inc.,
Rahway, NJ, USA. Please note that while Dr. Buchwald is employed and has stock and/or
stock options with Merck, Merck did not fund any portion of the study described in
this manuscript. The specific roles of these authors are articulated in the ‘author
contributions’ section.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Drugs
Subject:
Antimalarials
Subject:
Artesunate
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Parasitic Diseases
Subject:
Malaria
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Tropical Diseases
Subject:
Malaria
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
Subject:
Medicine and Health Sciences
Subject:
Urology
Subject:
Genitourinary Infections
Subject:
Human Papillomavirus Infection
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Sexually Transmitted Diseases
Subject:
Human Papillomavirus Infection
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Viral Diseases
Subject:
Human Papillomavirus Infection
Subject:
Medicine and Health Sciences
Subject:
Clinical Medicine
Subject:
Signs and Symptoms
Subject:
Pain
Subject:
Abdominal Pain
Subject:
Medicine and Health Sciences
Subject:
Clinical Medicine
Subject:
Signs and Symptoms
Subject:
Nausea
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
DNA viruses
Subject:
Papillomaviruses
Subject:
HPV-1
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Papillomaviruses
Subject:
HPV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Papillomaviruses
Subject:
HPV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Papillomaviruses
Subject:
HPV-1
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Anal and Rectal Disorders
