Cancer immunotherapy targeting neoantigens

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Abstract

Neoantigens are antigens that are encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens.

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Author and article information

Journal

Journal ID (nlm-journal-id): 9009458

Journal ID (pubmed-jr-id): 1183

Journal ID (nlm-ta): Semin Immunol

Journal ID (iso-abbrev): Semin. Immunol.

Title: Seminars in immunology

ISSN (Print): 1044-5323

ISSN (Electronic): 1096-3618

Publication date Nihms-submitted: 13 November 2015

Publication date (Electronic): 30 November 2015

Publication date (Print): February 2016

Publication date PMC-release: 01 February 2017

Volume: 28

Issue: 1

Pages: 22-27

Affiliations

[a ]Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

Author notes

[* ] Corresponding Authors: Yong-Chen Lu, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10-CRC, Rm 3W-3864, 10 Center Dr, Bethesda, MD, 20892. Tel.: +1 301 594-9476; Fax: +1 301 402-1738 Yong-Chen.Lu@ 123456nih.gov

Paul F. Robbins, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10-CRC, Rm 3W-5744, 10 Center Dr, Bethesda, MD, 20892. Tel.: +1 301 402-2069; Fax: +1 301 451-6949; Paul_Robbins@ 123456nih.gov

Article

Accession ID: PMC4862880 Pmcid ID: PMC4862880 Pmc-uid ID: 4862880 Manuscript ID: nihpa737023

DOI: 10.1016/j.smim.2015.11.002

PMC ID: 4862880

PubMed ID: 26653770

SO-VID: 70dd4756-5393-4f27-bc11-d35ab01f3ec7

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