Effective enterprise quality immune response can grasp the “pathogenesis”, “clinical manifestations” and “treatment” of enterprise quality dissident factors, which is the goal pursued continuously by enterprise quality management. Drawing on the theory of enterprise immunity, construct the evaluation index system of enterprise quality immune response effect, and use the evaluation model of interval binary semantic grey target decision based on two-dimensional association sampling (EMIBSGTD-TAS) to evaluate the quality immune response effect of the selected target company. The boundary and internal distribution situation weaken the influence of the extreme value of the index on the decision result, and introduce the interval binary semantic set value statistical method to determine the index weight, reduce the information loss and fuzzy error. It can be seen from the evaluation results that the model has practicability and feasibility, and provides a new idea for the evaluation of the effect of enterprise quality immune response.