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Abstract
Acute lung injury (ALI) and ARDS are defined by damage to the alveolar epithelium
and endothelium, which allows the exudation of protein-rich fluid into the alveolar
space. ALI/ARDS are life threatening inflammatory lung diseases, most commonly caused
by local or systemic inflammation, including pneumonia and sepsis. An uncontrolled
cytokine storm leads to detrimental effects such as cell death, epithelial and endothelial
barrier disruption, and edema. Lung repair and remodeling following ALI are crucial
steps and could be a risk factor for determining morbidity and mortality. During normal
repair and remodeling phases, alveolar fluid is reabsorbed and debris from dead cells
and pathogens is cleared by mononuclear-linage phagocytes. Additionally, endothelial
cells regenerate, epithelial cells proliferate and differentiate, and collagen fibers
are formed at site of injury. Finally, excess deposits of collagen fibers are processed
and removed.
Pulmonary edema is a major complication of ALI. Approaches aiming at improving and
maintaining endothelial and epithelial barrier integrity and function are in high
demand. The aim of this special issue is to illuminate pulmonary endothelium and epithelium
biological function during ALI, repair, and remodeling. We have selected 6 original
research manuscripts and 1 review article covering the range from basic research aspects
to translational studies and therapeutic evaluation.
ALI/ARDS is associated with a high mortality rate between 20 and 50% and is one of
the main clinical complications in severe malaria. M. L. M. Pereira et al. determine
the protective role of heme oxygenase-1 (HO-1) and HO-1 inducing drug, hemin, in malaria-associated
ALI. This study will potentially advance therapeutic approach in prevention of ALI/ARDS
development in severe malaria. In attempt to manage the uncontrolled cytokine storm
induced, a NEMO-binding domain peptide (NBD) was developed by J. Huang et al. to inhibit
LPS-induced NF-κB activation; NBD limits cytokine release, neutrophil infiltration,
and pulmonary vascular leakage in LPS-induced ALI mouse model. As an analysis of the
enhancement of endothelium barrier integrity aspect, L. Wang et al. have investigated
the protective role of pan-caspase inhibitor Q-VD in cytomix-induced pulmonary microvascular
endothelial cell permeability and apoptosis. In the review article, Y. Zhuang et al.
have addressed microRNA regulation in endothelial junction proteins and clinical consequence.
Lipid mediators, prostaglandin E2 (PGE2) and Leukotriene B4 (LTB4), play an important
role in host defense in many infections. The study by L. C. Rodrigues et al. has unveiled
that Gal-1 protects against histoplasmosis by maintaining the balance of nitric oxide
(NO) and PGE2. AM966 is an antagonist of lysophosphatidic acid receptor 1, which potentiates
antifibrotic function in experimental study. The study by J. Cai et al. has revealed
that AM966 treatment induces lung microvascular endothelial barrier disruption which
is regulated by RhoA/MLC and phosphorylation of VE-cadherin. Further, P. Geraghty
et al. demonstrate the ER stress in cigarette smoke-induced COPD.
In conclusion, many factors contribute to the pathogenesis of ALI/ARDS. It is important
to understand the pathophysiological mechanisms of ALI/ARDS to improve the outcome
of ALI patients. These special research articles were selected to offer readers updated
knowledge on new therapeutic approach development for ALI/ARDS and precaution in clinical
trial medicine.
Yutong Zhao
Karen Ridge
Jing Zhao
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