Paeonia lactiflora Pall. Polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3/ASC/Caspase-1 signaling pathway and affecting the composition of their intestinal flora.

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Abstract

Paeonia lactiflora Pall. (PL) has been commonly used to de-stressing the liver and relieve depression in traditional Chinese medicine for over a thousand years. Recently, it has been widely used in studies on anti-depressant, anti-inflammatory and regulation of intestinal flora. However, the polysaccharide component has received less attention than the saponin component of PL.

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Journal

Journal ID (iso-abbrev): J Ethnopharmacol

Title: Journal of ethnopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1872-7573

ISSN (Print): 0378-8741

Publication date (Electronic): Nov 15 2023

Volume: 316

Affiliations

[1 ] College of Pharmacy, Medicinal Chemistry Laboratory, Jiamusi University, 154007, Jiamusi, China.

[2 ] Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation, Jiamusi University, 154007, Jiamusi, China.

[3 ] Heilongjiang Provincial Key Laboratory of New Drug Development and Pharmacotoxicological Evaluation, Jiamusi University, 154007, Jiamusi, China. Electronic address: 0316zh@163.com.

[4 ] College of Pharmacy, Medicinal Chemistry Laboratory, Jiamusi University, 154007, Jiamusi, China. Electronic address: zhangyu@jmsu.edu.cn.

Article

Publisher Item ID: S0378-8741(23)00584-6

DOI: 10.1016/j.jep.2023.116716

PubMed ID: 37295570

SO-VID: 6f9848c0-c6df-4195-aba2-97a48b8ec417

History

Keywords: NLRP3 inflammasome,Paeonia lactiflora Pall.,Intestinal flora,Depression,16S rRNA

Data availability:

Keywords: NLRP3 inflammasome, Paeonia lactiflora Pall., Intestinal flora, Depression, 16S rRNA

Paeonia lactiflora Pall. Polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3/ASC/Caspase-1 signaling pathway and affecting the composition of their intestinal flora.

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