Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

Patel, Jay P; Gonen, Mithat; Figueroa, María E; Fernández, Hugo Alejandro; Sun, Zhuoxin; Racevskis, Janis; Van Vlierberghe, Pieter; Dolgalev, Igor; Thomas, Sabrena; Aminova, Olga; Huberman, Kety; Cheng, Janice M.H.; Viale, Agnes; Socci, Nicholas D.; Heguy, Adriana; Cherry, Athena; Vance, Gail H.; Higgins, Rodney R.; Ketterling, Rhett P.; Gallagher, Robert E; Litzow, Mark L; van den Brink, Marcel R. M. RM; Lazarus, Hillard M.; Rowe, Jacob M; Luger, Selina M; Ferrando, Adolfo; Paietta, Elisabeth; Tallman, Martin S.; Melnick, Ari M.; Abdel-Wahab, Omar; Levine, Ross L.

doi:10.1056/NEJMoa1112304

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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

Author(s): Jay Patel, Mithat Gonen, María Figueroa, Hugo Alejandro Fernández, Zhuoxin Sun, Janis Racevskis, Pieter Van Vlierberghe, Igor Dolgalev, Sabrena Thomas, Olga Aminova, Kety Huberman, Janice M.H. Cheng, Agnes Viale, Nicholas D. Socci, Adriana Heguy, Athena Cherry, Gail H. Vance, Rodney Higgins, Rhett Ketterling, Robert E Gallagher, Mark L Litzow, Marcel van den Brink, Hillard M. Lazarus, Jacob M Rowe, Selina M Luger, Adolfo Ferrando, Elisabeth Paietta, Martin S. Tallman, Ari Melnick, Omar Abdel-Wahab, Ross Levine

Publication date: 2012-03-22

Journal: The New England journal of medicine

Publisher: Massachusetts Medical Society

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Abstract

Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated in a phase 3 trial of treatment for AML.

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PubMed ID:: 22417203

PMC ID:: 3545649

DOI:: 10.1056/NEJMoa1112304

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