The burning ethical question raised by the COVID-19 pandemic is how to deal fairly
and ethically with a large number of patients simultaneously becoming critically unwell.
Across the world, in both developed and developing countries, health systems are grappling
with the possibility or the reality that the demand for intensive medical care will
outstrip availability. There is a need for ethical guidelines on how to allocate treatment,
but such guidelines are potentially highly controversial.
1
In this commentary, we set out a simple algorithm (Figure 1
), including what we take to be the essential ethical principles that ought to guide
resource allocation in any country or setting as well as optional elements that will
vary between countries depending on the weight placed on different ethical values
(Table 1
).
Figure 1
.
Figure 1
Table 1
Comparison of ventilator/intensive care allocation guidelines proposed or being applied
in the setting of the COVID-19 pandemic.
Table 1
First level Triage
Second level principles (tie break or supplementary)
Pandemic allocation guidelines
Probability of survival
Duration of therapy required
Life-years/Quality
Reciprocity (priority to health workers or young)
Equal share - Fixed duration (time-limited trial)
Equal chance (lottery or first-come-first-served)
SIAARTI (Italy),
2
Clinical ethics recommendations for the allocation of intensive care treatments in
exceptional, resource-limited circumstances
✓ Comorbidities, functional status, Age (no specific cut off)
X
✓
X
✓ICU trial (daily re-evaluation)
X
NICE (UK)
3
COVID-19 rapid guideline: critical care in adults
✓ Frailty (not applied to younger people, stable long-term disabilities, learning
disabilities and autism), Comorbidities, Severity of acute illness
X
X
X
Review of treatment suggested
X
University of Pittsburgh (US)
4
Allocation of scarce critical care resources during a public health emergency
✓SOFA scores, comorbidities
X
X
✓Both
Periodic reassessment
X
Daugherty and colleagues (US)
5
Too Many Patients…A Framework To Guide Statewide Allocation Of Scarce Mechanical Ventilation
During Disasters
✓Likelihood of short-term survival (SOFA scores), likelihood of long-term survival
(severe comorbidities)
X
X
✓Life-cycle preference for youngPregnant women
X
✓After other principles
Emanuel and colleagues (XX)
6
Fair Allocation of Scarce Medical Resources in the Time of Covid-19
✓
X
✓Life-years only in comparing patients whose likelihood of survival is similarNo evaluation
of QoL or QALY
✓Priority to health care workers when other factors similar;Youngest first when it
aligns with maximizing benefits
✓
✓No first-come first-served;Random selection among patients with similar prognosis
New York State Task Force on Life and the Law, New York State Department of Health
7
Ventilator allocation guidelines
✓Likelihood of short-term survival (SOFA scores)
X
X
✓Young age may be considered as a tie-breaking criterion in limited circumstances
✓Review at 48 and 120 h
✓ Lottery after other principles
Support patient autonomy
When a competent patient presents with a diagnosis (e.g. viral pneumonia), they should
be provided with the facts about the available treatments and given the opportunity
to express their personal wishes, priorities and values. Requests may not be able
to be accommodated, but competent refusals must be respected. Refusal can be contemporaneous,
or through a valid advance directive or legally appointed surrogate if they are incompetent.
Where possible, patient values should be elicited about what quality of life they
would judge acceptable following intensive medical treatment.
Assess urgency, delay non-urgent treatment
If clinical need is nonurgent, a trial of lower levels of care (e.g. continuous positive
airway pressure (CPAP), noninvasive ventilation) should be instituted to reduce demand
on critical care. A treatment escalation plan should be in place in case they subsequently
deteriorate.
Consider availability of resource
The resource (CPAP, ventilator, ICU care, extracorporeal membrane oxygenation (ECMO),
organ support) is either sufficient for the needs of all relevant patients or it is
not. If it is sufficient, then a principle of equal treatment for equal need applies.
In intensive care, this principle will often take the form of ‘first come, first served’,
allocating preferentially to those arriving first for medical attention.
If there are insufficient resources, one solution would be to increase availability.
Where this is not possible (or has already occurred, and resources are still insufficient),
‘first come, first served’ would mean that patients with poor prognosis, requiring
long periods of treatment be treated at the expense of patients arriving later with
much better prognosis. This will inevitably mean a reduction in the number of lives
saved. It would also be unfair because when someone happens to fall ill (earlier or
later) would decide allocation. According to principle of temporal neutrality,
8
when a harm occurs should not make a moral difference. In an accompanying paper,
1
we discuss a number of other shortcomings of ‘first come, first served’ when there
are limited resources.
First level allocation: save the most lives
The first ethical principle for allocation aims to maximise the numbers of lives saved.
This is a basic principle endorsed by triage in settings of overwhelming medical need
(for example disaster, battlefields or pandemics). It is supported by both popular
intuition and multiple ethical theories, as we now show.
Imagine you are manning the sole coastguard boat on duty. Two boats have overturned
some distance from each other. There are five people in one life raft due north and
some 50 miles away due south, another single person is on a life raft. A storm is
brewing and it is likely that you will only be able to get to one life raft before
the storm overturns them and the sailors drown. Which direction should you go? Some
years ago, when we asked a random sample of the public, 98% of respondents (88/90)
elected to save five drowning people rather than one person; only 2% elected to toss
a coin to decide.
9
According to utilitarianism, resources should be distributed to bring about the most
good: the greatest good to the greatest number. But non-utilitarian theories can also
recognise the importance of this principle. According to a contractualist approach,
the right distribution is the one we would choose from behind a ‘veil of ignorance’,
that is, if we did not know who we would be in society. From behind the veil, rational
self-interest requires that you choose the policy that gives you the greatest chance
of surviving.
We should save more lives rather than fewer, other things being equal. We can call
this the moral requirement to save the greatest number. It should be a universal requirement
of rationing. In practice, saving the greatest number logically entails saving those
patients with a higher probability of surviving. Imagine one group, A, has a 90% chance
of surviving with treatment, and another group, B, has a 10%. For every 10 people
treated in group A, 9 will survive, but only one will survive from B.
Saving the greatest number also requires estimating patients’ duration of treatment
and other resource use, since longer duration of therapy means fewer patients can
be treated. Imagine patients in group A take 1 week to recover and patients in B take
2 weeks. We can save two patients in group A for every one patient in B. Group A patients,
like those with higher probability, should have priority.
These two factors affecting number saved can be combined in the concept of a Resource
Adjusted Probability Ratio (RAPR).
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The concept captures that patients who have higher probabilities of survival and are
expected to recover quickly (freeing up the resources for others) should have highest
priority. Length of stay is a good proxy for resource use. For example, if a patient
has a 50% chance of survival and the predicted length of stay is 10 days, whereas
the average length of stay is 5 days, the RAPR is 25%.
Different patient factors may predict prognosis, for example, biological age, frailty,
and comorbidity may reduce the RAPR in patients with COVID-19 respiratory failure.
Any factor that reduces probability of survival or increases resource use is relevant
at this stage. This is the ethical justification for recent NICE guidance to consider
not providing intensive care to patients with high frailty scores.
2
Would this be discriminatory?
It would be discriminatory to include criteria in allocation that are not ethically
relevant (for example race, sexuality, religion or political beliefs). However, it
is not discrimination to use patient characteristics to estimate prognosis unless
a characteristic is used to systematically disadvantage a group. For example, age
per se (without consideration of prognosis) would be ageist and arguably unlawful
discrimination under the Equality Act 2010.
10
But using probability of survival is an ethically defensible criterion.
Based on the RAPR, patients could be classified into three categories. Those whom
clinicians are confident have a high probability of survival (and low resource use)
should receive the life sustaining treatment (LST). For example, this might be approximately
>80% survival but the absolute threshold will be relative to the numbers of patients
needing the life sustaining treatment resource and the availability of the resource
at a time. In cases of extreme scarcity, it may be that only those with >90% chance
of survival can be treated, while in health systems with greater resources relative
to demand, the threshold could be lower. The figure may vary across a time in one
institution as the resource availability may change.
Those in the low probability survival group (and high resource use) would usually
be given lower levels of care such as ward care or palliative care. Again, the actual
figure used to indicate low priority will be relative to resource availability. It
might be those with <10% survival but as low as <5% in conditions of relative abundance.
We recognise that there are significant error margins around any figure. Prognostic
uncertainty is one of the major problems of a decision-making process for resource
allocation,
11
but still we must reduce it to a minimum and then we should tolerate the residual
uncertainty.
Second level allocation – selection of which patients to save
The first level of allocation aims at saving the greatest number. High RAPR patients
should receive the resource. But there may be more high RAPR patients than there are
ventilators. In this case, a different allocation procedure will be needed for this
group. Or there may be sufficient ventilators for this group but a large second group
of moderate RAPR patients who may not be able to all receive treatment. Principles
will be needed to select from this moderate group.
There are several possible policy options. Any or all of these could be employed and
will be employed in different jurisdictions depending on ethics (including values)
and laws of that society. All are potentially ethically defensible.
1.
Lottery. A simple lottery or ‘first come, first served’ could be used for this group,
or a selection of the group. (Since high priority patients have already been selected
for treatment, and low priority selected against treatment, such a lottery would have
less impact on overall survival.)
2.
Second triage. This could involve either, or both, or sequential assessment of predicted
length and quality of life. Utilitarians consider both the expected increase in length
and quality of life to be relevant. For example, one could set a minimum of 5 years
expected of life after treatment as a threshold. This could be used to decide amongst
moderate prognosis candidates. Quality of life could also be considered. For example,
those with severe impairments of cognition or consciousness (such as late dementia)
would not be candidates on this criterion. This may or may not be lawful depending
on the legal jurisdiction.
10
This option will maximize the Quality Adjusted Life Years (QALYs), a standard metric
of evaluating the effectiveness of health interventions and used in other areas for
resource allocation and decisions about distributive justice.
3.
Priority. Priority could be accorded on utilitarian or desert-based grounds to health
care workers who have contracted COVID-19 in the course of their work. Priority could
also be accorded to younger patients just because they have enjoyed less life, that
is, on grounds of desert. For example, the Pittsburgh guidelines recommend the following
categories: age 12-40, age 41-60; age 61-75; older than age 75.
4
4.
Trial of Treatment. Some consideration of equality of opportunity could be afforded
to those with uncertain or moderate chances of survival by offering a fixed term trial
of treatment followed by withdrawal. This would address consideration of excessive
resource use and still give poorer prognosis patients a chance.
Some of these features (e.g. age) have already contributed to an assessment of probability
of survival in the first stage of allocation. In this second phase, they operate more
directly. For example, age might be used to prioritise some patients on the basis
of desert. That is, even if probability of survival were the same, this would give
weight to younger people based on desert considerations. Desert is related to fairness.
If you commit a crime, you deserve punishment. If you have had less cake (life), you
deserve more. Similarly, a severe cognitive impairment might reduce probability of
survival (and be included in the universal assessment) or it might be used as an optional
criterion of allocation. Severe cognitive impairment would also affect the ability
to appreciate the benefits of a successful treatment.
Quality of life is a hugely contested concept. Broadly, it can be construed subjectively
or objectively. Both concepts are ethically defensible and different societies will
accept different standards. A subjective assessment is determined by the patient themselves.
An objective assessment might include: absence of suffering, happiness, minimal cognitive
capacity, full consciousness, capacity to engage in meaningful human relationships.
12
It will be up to particular societies to decide whether quality of life should be
included or what standard should be employed.
Utilitarianism favours Second Triage and Priority (on grounds of utility, not desert).
Egalitarians favour Lottery. Trial of Treatment gives some consideration to both equality
and utility.
13
Decision-Making
Decision-making should be the clinician’s ultimate responsibility, in consultation
with patients, their families and colleagues. They will be best placed to know the
facts around patient numbers, need, urgency, resource availability, prognosis, likely
survival and future level of function.
However, decision making should be informed by the ethical principles and values proposed
in this algorithm. At a minimum, every reviewed proposal for allocation of ventilators
in the pandemic should include prioritisation of chance of survival. Differences between
countries in their chosen approach to allocation (Table 1) is inevitable, and will
reflect the ethical choices of particular societies. However, these values must be
made explicit and decisions not left to personal values, conscience, intuition, religion
or idiosyncrasy. Algorithmic ethics makes these values and their relationship explicit.
How these values are applied will depend on the facts. But we should as a society
agree on the ethical values and their relationship. As events such as the COVID-19
pandemic befall us, our values and choices play a significant role in determining
who lives and who dies.
Authors’ contributions
JS conceived of and drafted the algorithm. DW conceived of the table. DW and JS constructed
a first draft. DW, MV elaborated arguments and added clinical detail. LC developed
arguments and constructed a comparative table. All authors revised the document for
critical intellectual input and all authors approved the final version.
Declaration of interest
JS reports grants from Wellcome Trust and Uehiro Foundation on Ethics and Education.
The authors report no other conflicts.
Funding
JS and DW received support from the Uehiro Foundation on Ethics and Education, and
the Wellcome Trust via the Wellcome Centre for Ethics and Humanties (WT203132) and
JS from the Wellcome Trust via the Responsibility and Healthcare project (WT104848).
Through his involvement with the Murdoch Children's Research Institute, JS was supported
by the Victorian Government's Operational Infrastructure Support Program.