We study a hardware-efficient variational quantum algorithm ansatz tailored for the trapped-ion quantum simulator, HEA-TI. We leverage programmable single-qubit rotations and global spin-spin interactions among all ions, reducing the dependence on resource-intensive two-qubit gates in conventional gate-based methods. We apply HEA-TI to state engineering of cluster states and analyze the scaling of required quantum resources. We also apply HEA-TI to solve the ground state problem of chemical molecules \(\mathrm{H_{2}}\), \(\mathrm{LiH}\) and \(\mathrm{F_{2}}\). We numerically analyze the quantum computing resources required to achieve chemical accuracy and examine the performance under realistic experimental noise and statistical fluctuation. The efficiency of this ansatz is shown to be comparable to other commonly used variational ansatzes like UCCSD, with the advantage of substantially easier implementation in the trapped-ion quantum simulator. This approach showcases the hardware-efficient ansatz as a powerful tool for the application of the near-term quantum computer.