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      Giant calcifying epithelial odontogenic tumor after I-125 seed implantation: A case report

      case-report

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          Abstract

          Calcifying Epithelial Odontogenic Tumor (CEOT), also known as Pindborg tumor, is a rare odontogenic benign tumor. It was first reported by Thoma and Goldman in 1946 and defined as an independent tumor by Pindborg in 1957. Herein, we reported a CEOT case involving most of the mandible after I-125 implantation in a 53-year-old man. We cooperated with governmental and hospital departments to resect the tumors, reconstruct the mandible with a fibular flap graft, and properly dispose of the radioactive particles.

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          Calcifying epithelial odontogenic tumour: biological profile based on 181 cases from the literature.

          H Philipsen, P Reichart (1999)
          The present profile of the calcifying epithelial odontogenic tumour (CEOT) is based on a literature survey of 181 published tumour cases. The CEOT is a benign, though occasional locally invasive, slow-growing neoplasm occurring as intraosseous (94%) and extraosseous (6%) variants. The intraosseous type appears radiographically as an irregular, uni- or multilocular radiolucent area containing radiopaque masses which increases in size and opacity with time. Some 60% of intraosseous CEOT are associated with an unerupted tooth (or odontoma). CEOT shows a relative frequency of 1-2%. The extraosseous variant is diagnosed slightly earlier (mean age 34.4 years) than the intraosseous type (mean age 38.9 years). Both variants have an almost 1:1 gender ratio. The intraosseous CEOT shows a maxilla:mandible site ratio of 1:2 and are mainly located in the premolar/molar region. The present authors present evidence that the CEOT originates from the complex system of dental laminae or remnants thereof. Histologically, the CEOT is characterized by the occurrence of sheets, nests and masses of polyhedral, eosinophilic epithelial cells which may show cellular abnormalities including giant cell formation and nuclear pleomorphism. Some cells increase in size and produce a homogeneous, eosinophilic, 'amyloid-like' substance which may become calcified and which may be liberated as the cells break down. The true nature of the amyloid-like material is still unresolved. Histological variants including CEOT with cementum-like components, clear-cell CEOT (15 cases reported so far), CEOT-containing Langerhans' cells, combined epithelial odontogenic tumour (CEOT/AOT) and CEOT with myoepithelial cells are discussed in detail. In view of the relatively indolent biological behaviour of the CEOT, mutilating procedures, such as wide resection or hemisection of the mandible, seem unwarranted. Enucleation with a margin of macroscopically normal tissue is, therefore, the recommended treatment for CEOT involving the mandible. Maxillary CEOT should, however, be treated more aggressively, as they tend to grow more rapidly and do not usually remain well confined. Generally, recurrences are rare. Five years is considered the absolute minimum follow-up period. The survey has revealed only one well-documented case of a mandibular CEOT in a 75-year-old man showing features of malignancy.
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            Mandible reconstruction with free fibula flaps: Outcome of a cost-effective individual planning concept compared with virtual surgical planning.

            Niklas Rommel, Marco Kesting, Nils Hagen Rohleder … (2017)
            The free osteomyocutaneous fibular flap has become one of the primary options for mandibular reconstruction, because of the later introduction and development of virtual surgical planning (VSP). However, VSP is associated with high additional pre-operative effort and costs. Therefore, the purpose of the study was to develop a new individual cost-effective pre-operative planning concept for free fibula mandible reconstruction and to compare it with VSP regarding clinical parameters and post-operative outcome.
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              Calcifying epithelial odontogenic tumor: An updated analysis of 339 cases reported in the literature

              Bruno Chrcanovic, Ricardo Gomez (2017)
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                Author and article information

                Contributors
                Yanchen Li
                Kuo Wan
                Mu Wang
                Geping Cui
                Bo Chen
                Lijiang Yu
                Yindong Liu
                Haitao Dong
                Zhihui Zhu
                Ruiqi Zhao
                Tao Zhang
                Journal
                Journal ID (nlm-ta): Heliyon
                Journal ID (iso-abbrev): Heliyon
                Title: Heliyon
                Publisher: Elsevier
                ISSN (Electronic): 2405-8440
                Publication date PMC-release: 20 June 2023
                Publication date Collection: July 2023
                Publication date (Electronic): 20 June 2023
                Volume: 9
                Issue: 7
                Electronic Location Identifier: e17087
                Affiliations
                [a ]Department of Stomatology, Peking Union Medical College Hospital, Peking Union Medical College&Chinese Academy of Medical Sciences, Beijing, China
                [b ]Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
                Author notes
                [∗ ]Corresponding author. No.1 Shuaifuyuan Dongcheng District, Beijing, 100730, China. drtzhang@ 123456126.com
                Article
                Publisher Item ID: S2405-8440(23)04295-0 Publisher ID: e17087
                DOI: 10.1016/j.heliyon.2023.e17087
                PMC ID: 10338303
                SO-VID: 6e336bda-82cb-4a6b-83d2-8f3336fade98
                Copyright © © 2023 The Authors
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 31 January 2023
                Date revision received : 18 May 2023
                Date accepted : 7 June 2023
                Categories
                Subject: Case Report

                Keywords: calcifying epithelial odontogenic tumor,free fibular flap,i-125,case report
                Data availability:
                Keywords: calcifying epithelial odontogenic tumor, free fibular flap, i-125, case report

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