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      New Dogs in the Dogma: Lrp4 and Tid1 in Neuromuscular Synapse Formation

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      Neuron
      Elsevier BV

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          Abstract

          Two recent papers reported identification of a long-sought agrin coreceptor, Lrp4 (Kim et al. in Cell and Zhang et al. in Neuron). In this issue of Neuron, Linnoila et al. report the identification of a new player in the agrin-MuSK pathway, Tid1, which directly interacts with MuSK and is responsible for transducing signals from MuSK activation to AChR clustering, culminating in cross-linking to the subsynaptic cytoskeleton. These papers substantially reshape the agrin-MuSK-ACh hypothesis of neuromuscular synaptogenesis.

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          Author and article information

          Journal
          Neuron
          Neuron
          Elsevier BV
          08966273
          November 2008
          November 2008
          : 60
          : 4
          : 526-528
          Article
          10.1016/j.neuron.2008.11.003
          19038209
          6db28461-253c-434e-b0f7-5e8fe573d689
          © 2008

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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