For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
5
views
41
references
 Top references
cited by
5
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      359
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome

      research-article
      Author(s): 1 , 2 , , 1 , 2 , 1 , 1 , 2
      Publication date (Electronic):
      Journal: Journal of Obesity
      Publisher: Hindawi

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Objective

          To analyze the ventilatory and alveolar-capillary diffusion dysfunctions in case of obesity with or without an OSAS.

          Methods

          It is a cross-sectional study of 48 obese adults (23 OSAS and 25 controls). Anthropometric data (height, weight, and body mass index (BMI)) were collected. All adults responded to a medical questionnaire and underwent polysomnography or sleep polygraphy for apnea-hypopnea index (AHI) and percentage of desaturation measurements. The following lung function data were collected: pulmonary flows and volumes, lung transfer factor for carbon monoxide (DLCO), and fraction of exhaled nitric oxide (F eNO).

          Results

          Obesity was confirmed for the two groups with a total sample mean value of BMI = 35.06 ± 4.68 kg/m 2. A significant decrease in lung function was noted in patients with OSAS compared with controls. Indeed, when compared with the control group, the OSAS one had a severe restrictive ventilatory defect (total lung capacity: 93 ± 14 vs. 79 ± 12%), an abnormal DLCO (112 ± 20 vs. 93 ± 22%), and higher bronchial inflammation (18.40 ± 9.20 vs. 31.30 ± 13.60 ppb) ( p < 0.05).

          Conclusion

          Obesity when associated with OSAS increases the severity of pulmonary function and alveolar-capillary diffusion alteration. This can be explained in part by the alveolar inflammation.

          Related collections

          Most cited references41

          • Record: found
          • Abstract: found
          • Article: not found

          Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women.

          Terry Young, Linda Evans, Laurel Ann Finn … (1997)
          The proportion of sleep apnea syndrome (SAS) in the general adult population that goes undiagnosed was estimated from a sample of 4,925 employed adults. Questionnaire data on doctor-diagnosed sleep apnea were followed up to ascertain the prevalence of diagnosed sleep apnea. In-laboratory polysomnography on a subset of 1,090 participants was used to estimate screen-detected sleep apnea. In this population, without obvious barriers to health care for sleep disorders, we estimate that 93% of women and 82% of men with moderate to severe SAS have not been clinically diagnosed. These findings provide a baseline for assessing health care resource needs for sleep apnea.
          Article 0 comments Cited 287 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr.

            J. Durán, S Esnaola, R Rubio … (2001)
            The prevalence and related clinical features of obstructive sleep apnea-hypopnea (OSAH) in the general population were estimated in a two-phase cross-sectional study. The first phase, completed by 2,148 subjects (76.9%), included a home survey, blood pressure, and a portable respiratory recording, whereas in the second, subjects with suspected OSAH (n = 442) and a subgroup of those with normal results (n = 305) were invited to undergo polysomnography (555 accepted). Habitual snoring was found in 35% of the population and breathing pauses in 6%. Both features occurred more frequently in men, showed a trend to increase with age, and were significantly associated with OSAH. Daytime hypersomnolence occurred in 18% of the subjects and was not associated with OSAH. An apnea-hypopnea index (AHI) > or = 10 was found in 19% of men and 15% of women. The prevalence of OSAH (AHI > or = 5) increased with age in both sexes, with an odds ratio (OR) of 2.2 for each 10-yr increase. AHI was associated with hypertension after adjusting for age, sex, body mass index, neck circumference, alcohol use, and smoking habit. This study adds evidence for a link between OSAH and hypertension.
            Article 0 comments Cited 244 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome.

              Luciano Drager, Sonia Togeiro, Vsevolod Polotsky … (2013)
              Obstructive sleep apnea (OSA) is an underdiagnosed condition characterized by recurrent episodes of obstruction of the upper airway leading to sleep fragmentation and intermittent hypoxia during sleep. Obesity predisposes to OSA, and the prevalence of OSA is increasing worldwide because of the ongoing epidemic of obesity. Recent evidence has shown that surrogate markers of cardiovascular risk, including sympathetic activation, systemic inflammation, and endothelial dysfunction, are significantly increased in obese patients with OSA versus those without OSA, suggesting that OSA is not simply an epiphenomenon of obesity. Moreover, findings from animal models and patients with OSA show that intermittent hypoxia exacerbates the metabolic dysfunction of obesity, augmenting insulin resistance and nonalcoholic fatty liver disease. In patients with the metabolic syndrome, the prevalence of moderate to severe OSA is very high (∼60%). In this population, OSA is independently associated with increased glucose and triglyceride levels as well as markers of inflammation, arterial stiffness, and atherosclerosis. A recent randomized, controlled, crossover study showed that effective treatment of OSA with continuous positive airway pressure for 3 months significantly reduced several components of the metabolic syndrome, including blood pressure, triglyceride levels, and visceral fat. Finally, several cohort studies have consistently shown that OSA is associated with increased cardiovascular mortality, independent of obesity. Taken together, these results support the concept that OSA exacerbates the cardiometabolic risk attributed to obesity and the metabolic syndrome. Recognition and treatment of OSA may decrease the cardiovascular risk in obese patients. Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
              Article 0 comments Cited 223 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Sonia Rouatbi:
                ORCID: https://orcid.org/0000-0003-1347-0100
                Journal
                Journal ID (nlm-ta): J Obes
                Journal ID (iso-abbrev): J Obes
                Journal ID (publisher-id): JOBE
                Title: Journal of Obesity
                Publisher: Hindawi
                ISSN (Print): 2090-0708
                ISSN (Electronic): 2090-0716
                Publication date Collection: 2020
                Publication date (Electronic): 10 February 2020
                Volume: 2020
                Electronic Location Identifier: 8075482
                Affiliations
                1Laboratory of Physiology and Explorations, Faculty of Medicine Sousse, University of Sousse, Sousse, Tunisia
                2Heart Failure (LR12SP09) Research Laboratory, Farhat Hached Hospital, Sousse, Tunisia
                Author notes

                Academic Editor: Mario Musella

                Author information
                https://orcid.org/0000-0003-1347-0100
                https://orcid.org/0000-0002-7477-2965
                Article
                DOI: 10.1155/2020/8075482
                PMC ID: 7035560
                PubMed ID: 32104601
                SO-VID: 6d6e3909-631d-4f29-98a5-dd5c3b50cb36
                Copyright © Copyright © 2020 Sonia Rouatbi et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 2 July 2019
                Date revision received : 11 January 2020
                Date accepted : 14 January 2020
                Categories
                Subject: Research Article

                ScienceOpen disciplines: Nutrition & Dietetics
                Data availability:
                ScienceOpen disciplines: Nutrition & Dietetics

                Comments

                Comment on this article

                scite_

                Similar content359

                See all similar

                Cited by5

                See all cited by

                Most referenced authors787

                See all reference authors