Propofol Anesthesia Alters Spatial and Topologic Organization of Rat Brain Metabolism.

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Abstract

Loss of consciousness during anesthesia reduces local and global rate of cerebral glucose metabolism. Despite this, the influence of gradual anesthetic-induced changes on consciousness across the entire brain metabolic network has barely been studied. The purpose of the present study was to identify specific cerebral metabolic patterns characteristic of different consciousness/anesthesia states induced by intravenous anesthetic propofol.

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Journal

Journal ID (iso-abbrev): Anesthesiology

Title: Anesthesiology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1528-1175

ISSN (Print): 0003-3022

Publication date (Electronic): October 2019

Volume: 131

Issue: 4

Affiliations

[1 ] From the Department of Anesthesiology (Y.C.), the Positron Emission Tomography Center (W.B.), and the Department of Anesthesiology (J.Z.), Huashan Hospital, Fudan University, Shanghai, China; and the Laboratory for Space Environment and Physical Science, Harbin Institute of Technology, Harbin, China (X.L.).

Article

DOI: 10.1097/ALN.0000000000002876

PubMed ID: 31343459

SO-VID: 6d6c528a-bac0-4802-9571-94afa9ede5b3

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