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A potential relationship between gut microbes and atrial fibrillation: Trimethylamine N-oxide, a gut microbe-derived metabolite, facilitates the progression of atrial fibrillation
Lilei Yu ,
Guannan Meng ,
Bing Huang ,
Xiaoya Zhou ,
Stavros Stavrakis ,
Menglong Wang ,
Xuefei Li ,
Liping Zhou ,
Yuhong Wang ,
Meng Wang ,
Zhenya Wang ,
Jielin Deng ,
Sunny S. Po ,
Hong Jiang
March 2018
March 2018
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Abstract
<p class="first" id="d5461340e182">Emerging evidence indicates gut microbes and their
products could activate the autonomic
nervous system (ANS), which plays important roles in the initiation and maintenance
of atrial fibrillation (AF). Trimethylamine N-oxide (TMAO), a metabolite derived from
gut microbes, is associated with cardiovascular diseases. The present study aimed
to investigate the role of TMAO in the progression of AF.
</p>