Contributors
Melanie Ricke-Hoch:
ORCID: https://orcid.org/0000-0001-5479-2275
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole:
VisualizationRole: Writing – original draftRole: Writing – review & editing
Elisabeth Stelling: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: ValidationRole: VisualizationRole: Writing – original draftRole:
Writing – review & editing
Lisa Lasswitz: Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draft
Antonia P. Gunesch: Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – original draft
Martina Kasten: Role: Data curation
Francisco J. Zapatero-Belinchón: Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – review & editing
Graham Brogden: Role: Formal analysisRole: InvestigationRole: MethodologyRole: ResourcesRole: VisualizationRole:
Writing – review & editing
Gisa Gerold:
ORCID: https://orcid.org/0000-0002-1326-5038
Role: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: Writing
– review & editing
Thomas Pietschmann: Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: SupervisionRole:
Writing – review & editing
Virginie Montiel: Role: ResourcesRole: Writing – review & editing
Jean-Luc Balligand: Role: Funding acquisitionRole: ResourcesRole: Writing – review & editing
Federica Facciotti: Role: InvestigationRole: Resources
Emilio Hirsch: Role: ConceptualizationRole: Funding acquisitionRole: Resources
Thomas Gausepohl:
ORCID: https://orcid.org/0000-0003-1669-5911
Role: Data curationRole: Writing – review & editing
Husni Elbahesh:
ORCID: https://orcid.org/0000-0003-1243-0967
Role: InvestigationRole: MethodologyRole: Writing – original draftRole: Writing –
review & editing
Guus F. Rimmelzwaan: Role: Funding acquisitionRole: InvestigationRole: Writing – review & editing
Anne Höfer: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing
– review & editing
Mark P. Kühnel: Role: Funding acquisitionRole: ResourcesRole: SupervisionRole: Writing – original
draftRole: Writing – review & editing
Danny Jonigk: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Julian Eigendorf: Role: Data curationRole: InvestigationRole: Project administrationRole: Writing –
review & editing
Uwe Tegtbur: Role: ConceptualizationRole: InvestigationRole: Project administrationRole: ResourcesRole:
Writing – review & editing
Lena Mink: Role: Data curationRole: InvestigationRole: ResourcesRole: Writing – review & editing
Michaela Scherr: Role: Data curationRole: Visualization
Thomas Illig: Role: Funding acquisitionRole: MethodologyRole: ResourcesRole: Writing – review &
editing
Axel Schambach: Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
Tobias J. Pfeffer: Role: Data curationRole: InvestigationRole: ResourcesRole: Writing – review & editing
Andres Hilfiker: Role: MethodologyRole: ResourcesRole: Writing – review & editing
Axel Haverich: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: ResourcesRole: Writing
– review & editing
Denise Hilfiker-Kleiner: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole:
VisualizationRole: Writing – original draftRole: Writing – review & editing
Paulo Lee Ho: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
4
August
2021
Publication date Collection: 2021
Publication date PMC-release: 4
August
2021
Volume: 16
Issue: 8
Electronic Location Identifier: e0255335
Affiliations
[1
]
Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany
[2
]
Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical
Infection Research Hannover, Hanover, Germany
[3
]
German Center for Infection Research, Hanover-Braunschweig Site, Braunschweig, Germany
[4
]
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School,
Hanover, Germany
[5
]
Department of Clinical Microbiology, Virology & Wallenberg Centre for Molecular Medicine
(WCMM), Umeå University, Umeå, Sweden
[6
]
Department of Biochemistry, University of Veterinary Medicine Hannover, Hanover Germany
[7
]
Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique,
and Cliniques Universitaires Saint-Luc, Université catholique de Louvain (UCLouvain),
Brussels, Belgium
[8
]
Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan,
Italy
[9
]
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology
Center, University of Torino, Torino, Italy
[10
]
Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary
Medicine in Hannover (TiHo), Hannover, Germany
[11
]
Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center
for Lung Research, Hanover, Germany
[12
]
Institute for Pathology, Hannover Medical School, Hanover, Germany
[13
]
Institute of Sports Medicine, Hannover Medical School, Hanover, Germany
[14
]
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover
Medical School, Hanover, Germany
[15
]
Hannover Unified Biobank (HUB), Hannover Medical School, Hanover, Germany
[16
]
Institute of Experimental Hematology, Hannover Medical School, Hanover, Germany
[17
]
Division of Hematology and Oncology, Boston Children’s Hospital, Harvard Medical School,
Boston, MA, United States of America
[18
]
Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical
School, Hanover, Germany
[19
]
Department of Cardiovascular Complications of Oncologic Therapies, Medical Faculty
of the Philipps University Marburg, Marburg, Germany
Instituto Butantan, BRAZIL
Author notes
Competing Interests: The authors have declared that no competing interests exist.
‡ SIGR and MK contributed equally to this work as first co-authors.
Author information
Article
Publisher ID:
PONE-D-21-08028
DOI: 10.1371/journal.pone.0255335
PMC ID: 8336874
PubMed ID: 34347801
SO-VID: 6c61cae6-f8b5-4eb1-9404-0fb8b439f6c4
Copyright © © 2021 Ricke-Hoch et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 11
March
2021
Date
accepted
: 14
July
2021
Page count
Figures: 6,
Tables: 1,
Pages: 24
Funding
Funded by:
funder-id http://dx.doi.org/10.13039/501100001659, Deutsche Forschungsgemeinschaft;
Award ID: HI 842/3-2
Award Recipient
:
Denise Hilfiker-Kleiner
Funded by:
funder-id http://dx.doi.org/10.13039/501100001659, Deutsche Forschungsgemeinschaft;
Award ID: HI 842/10-1
Award Recipient
:
Denise Hilfiker-Kleiner
Funded by:
funder-id http://dx.doi.org/10.13039/501100001659, Deutsche Forschungsgemeinschaft;
Award ID: HI 842/10-2
Award Recipient
:
Denise Hilfiker-Kleiner
Funded by:
funder-id http://dx.doi.org/10.13039/501100001659, Deutsche Forschungsgemeinschaft;
Award ID: RI 2531/2-1
Award Recipient
:
ORCID: https://orcid.org/0000-0001-5479-2275
Melanie Ricke-Hoch
Funded by:
funder-id http://dx.doi.org/10.13039/501100001659, Deutsche Forschungsgemeinschaft;
Award ID: RI 2531/2-2
Award Recipient
:
ORCID: https://orcid.org/0000-0001-5479-2275
Melanie Ricke-Hoch
Funded by:
funder-id http://dx.doi.org/10.13039/100011937, Niedersächsische Ministerium für Wissenschaft und Kultur;
Award ID: REBIRTH I/II
Award Recipient
:
Denise Hilfiker-Kleiner
Funded by:
Foundation Leducq
Award ID: ID 19CVD02
Award Recipient
:
Denise Hilfiker-Kleiner
Funded by:
foundation leducq
Award ID: ID 19CVD02
Award Recipient
:
Emilio Hirsch
Funded by:
funder-id http://dx.doi.org/10.13039/501100001659, Deutsche Forschungsgemeinschaft;
Award ID: EXC 2155 RESIST
Award Recipient
:
Danny Jonigk
Funded by:
The DEFEAT PANDEMIcs
Award ID: AP6-9
Award Recipient
:
Danny Jonigk
Funded by:
The DEFEAT PANDEMIcs
Award ID: AP6-9
Award Recipient
:
Mark P. Kühnel
Funded by:
funder-id http://dx.doi.org/10.13039/501100001659, Deutsche Forschungsgemeinschaft;
Award ID: GE 2145/3-2
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1326-5038
Gisa Gerold
Funded by:
funder-id http://dx.doi.org/10.13039/501100001659, Deutsche Forschungsgemeinschaft;
Award ID: Project 158989968
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1326-5038
Gisa Gerold
Funded by:
niedersächsische ministerium für wissenschaft und kultur and volkswagen foundation
Award ID: Project 76251-99-3/19
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1326-5038
Gisa Gerold
Funded by:
the knut and alice wallenberg foundation
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1326-5038
Gisa Gerold
Funded by:
funder-id http://dx.doi.org/10.13039/100010663, H2020 European Research Council;
Award ID: XHale 771883
Award Recipient
:
Danny Jonigk
Funded by:
funder-id http://dx.doi.org/10.13039/501100007601, Horizon 2020;
Award ID: No 871029
Funded by:
funder-id http://dx.doi.org/10.13039/100005156, Alexander von Humboldt-Stiftung;
Award ID: Alexander von Humboldt Professorship
Award Recipient
:
Guus F. Rimmelzwaan
Funded by:
funder-id http://dx.doi.org/10.13039/100011937, Niedersächsische Ministerium für Wissenschaft und Kultur;
Award ID: 14 - 76103-184 CORONA-15/20
Award Recipient
:
Guus F. Rimmelzwaan
Funded by:
federal ministry of education and research
Award ID: 01KI20143C
Award Recipient
:
ORCID: https://orcid.org/0000-0002-1326-5038
Gisa Gerold
Funded by:
funder-id http://dx.doi.org/10.13039/100009139, Deutsches Zentrum für Infektionsforschung;
Award ID: TTU 05.81600
Award Recipient
:
Thomas Pietschmann
Funded by:
Fonds National de la Recherche Scientifique and WEBIO
Award Recipient
:
Jean-Luc Balligand
Funded by:
cariplo foundation
Award ID: #2018-0498
Award Recipient
:
Emilio Hirsch
This work was supported by: The German Research Foundation (DFG, HI 842/3-2 to D.H.-K.),
by the DFG Clinical Research Group (DFG KFO311, HI 842/10-1, HI 842/10-2 to D.H.-K.;
RI 2531/2-1, RI 2531/2-2 to M.R.-H.), by REBIRTH I/II to D.H.-K., by the Foundation
Leducq (Project ID 19CVD02) to D.H.-K. and E.H., DFG as part of the German Strategy
for Excellence (EXC 2155 “RESIST”, Project ID 39087428 to D.J.), The DEFEAT PANDEMIcs
(AP6-9, to D.J. and M.P.K.), by the (DFG – Projektnummer 158989968 - SFB 900 project
C7 and DFG project GE 2145/3-2 to G.G.), the ‘Niedersächsischen Vorab’ program (project
76251-99-3/19 to G.G.) through the Ministry of Lower Saxony (MWK) and the Volkswagen
Foundation (Volkswagen Stiftung), by the Federal Ministry of education and research
(project COVID-Protect, Project: 01KI20143C to G.G.), the Knut and Alice Wallenberg
Foundation and the Federal Ministry of Education and Research together with the the
Ministry for Science and Culture (MWG) through the ‘Professorinnen Programm III’ to
G.G., by the European Research Council Consolidator Grant (XHale; 771883 to D.J.),
by REBIRTH I/II and REBIRTH Center for Regenerative Translational Medicine (MWK, project
ZN3440) to A.S., by Cariplo Foundation (Project #2018-0498 to E.H.), by MWG project
14-76103-184 CORONA-1/20 to T.I. and by the European Virus Archive GLOBAL (EVA-GLOBAL)
project funded by the European Union’s Horizon 2020 research and innovation program
under grant agreement No 871029 (to Christian Drosten). This work was partly supported
by the Alexander von Humboldt Foundation in the framework of the Alexander von Humboldt
Professorship endowed by the German Federal Ministry of Education and Research and
by funding from the Ministry for Science and Culture (MWK), Lower Saxony, Germany
(14 - 76103-184 CORONA-15/20 to G.F.R.). A.P.G. was supported by the Deutsches Zentrum
für Infektionsforschung (DZIF; German Center for Infection Research; Grant No. TTU
05.816 00 to T.P.). Work by J.L.B. was supported by grants from Fonds National de
la Recherche Scientifique (FNRS) and WEBIO. J.L.B is an established investigator of
the WELBIO institute. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
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