Cancer-specific promoters for expression-targeted gene therapy: ran, brms1 and mcm5.

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Abstract

To expand the library of promoters that can be used for expression-targeted gene delivery to cancer cells, the specificity and strength of expression of three cancer-related gene promoters was evaluated: RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 ((P) brms1) and minichromosome maintenance complex component 5 ((P) mcm5).

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Author and article information

Journal

Journal ID (iso-abbrev): J Gene Med

Title: The journal of gene medicine

Publisher: Wiley-Blackwell

ISSN (Electronic): 1521-2254

ISSN (Print): 1099-498X

Publication date (Electronic): Jul 2016

Volume: 18

Issue: 7

Affiliations

[1 ] Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA, USA.

[2 ] Department of Comparative Medicine, Tulane University, New Orleans, LA, USA.

[3 ] Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.

Article

DOI: 10.1002/jgm.2882

PubMed ID: 27140445

SO-VID: 6c5521b5-708d-4094-8a32-e12a7feb6bbc

History

Keywords: brms1,cancer,expression-targeting,gene therapy,mcm5,ran

Data availability:

Keywords: brms1, cancer, expression-targeting, gene therapy, mcm5, ran

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