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      Bone healing of mandibular critical-size defects in spontaneously hypertensive rats

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          Abstract

          Few articles have shown changes in bone metabolism caused by hypertension. The objective of this study was to investigate the relationship between hypertension and bone healing. Circular critical-size defects 5 mm and 2 mm in diameter were created, respectively, on the left and right side of the mandible in 40 spontaneously hypertensive and 40 control Wistar-Kyoto rats. Five animals from each strain were killed 2, 3, 5, 10, 15, 30, 60 and 90 days after surgery. The macroscopic evaluation showed great mandibular angle deformation on the left side and non-healed defects on both sides and groups. Histological evaluation revealed similar bone healing on both sides, with initial necrosis in the central area, and fibrosis and angiogenesis within the first 5 days. From the 10th postoperative day on, the newly formed bone displayed progressive thickening until the 90th postoperative day, when the defect margins presented a compact bone structure. Furthermore, the statistical analysis of the histometric data did not reveal any significant hypertension effect on bone healing in the defect area. These results suggest that bone healing was not different between spontaneously hypertensive rats and control rats.

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          Global burden of hypertension: analysis of worldwide data

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            Global burden of hypertension: analysis of worldwide data

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              Global burden of hypertension: analysis of worldwide data

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Journal
                bor
                Brazilian Oral Research
                Braz. oral res.
                Sociedade Brasileira de Pesquisa Odontológica - SBPqO (São Paulo )
                1807-3107
                September 2013
                : 27
                : 5
                : 423-430
                Affiliations
                [1 ] Universidade de São Paulo Brazil
                Article
                S1806-83242013000500423
                10.1590/S1806-83242013000500006
                6bb376d4-6b46-4b88-8847-2d113c25f60d

                http://creativecommons.org/licenses/by/4.0/

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                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=1806-8324&lng=en
                Categories
                DENTISTRY, ORAL SURGERY & MEDICINE

                Dentistry
                Bone Regeneration,Hypertension,Rats, Inbred SHR,Rats, Inbred WKY
                Dentistry
                Bone Regeneration, Hypertension, Rats, Inbred SHR, Rats, Inbred WKY

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