The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.

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Abstract

Cachexia, marked by muscle atrophy, poses substantial challenges for prevention and treatment. This study delves into the unclear role of butyrate, a gut microbiota metabolite, in cachexia by examining gut microbiota and short-chain fatty acid (SCFA) profiles in human and mouse fecal samples.

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Author and article information

Journal

Journal ID (iso-abbrev): Int Immunopharmacol

Title: International immunopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1878-1705

ISSN (Print): 1567-5769

Publication date (Electronic): Nov 2023

Volume: 124

Issue: Pt B

Affiliations

[1 ] Department of General Surgery/Shanghai Clinical Nutrition Research Center, Zhongshan Hospital, Fudan University, Shanghai, China.

[2 ] Department of Medicine, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan, Shandong, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China.

[3 ] Department of General Surgery/Shanghai Clinical Nutrition Research Center, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: dr_wugh@163.com.

Article

Publisher Item ID: S1567-5769(23)01326-7

DOI: 10.1016/j.intimp.2023.111001

PubMed ID: 37804658

SO-VID: 6ba5c03c-0462-4d73-bf6c-b11f6efe005d

History

Keywords: Gut microbiota,Muscle atrophy,Macrophages,Cachexia,Butyrate

Data availability:

Keywords: Gut microbiota, Muscle atrophy, Macrophages, Cachexia, Butyrate

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