Reduced Interhemispheric Functional Connectivity in Obsessive–Compulsive Disorder Patients

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Abstract

Background: Neuroimaging studies have shown that the high synchrony of spontaneous neural activity in the homotopic regions between hemispheres is an important functional structural feature of normal human brains, and this feature is abnormal in the patients with various mental disorders. However, little is known about this feature in obsessive–compulsive disorder (OCD). This study aimed to further analyze the underlying neural mechanisms of OCD and to explore whether clinical characteristics are correlated with the alerted homotopic connectivity in patients with OCD.

Methods: Using voxel-mirrored homotopic connectivity (VMHC) during resting state, we compared 46 OCD patients and 46 healthy controls (HCs) matched for age, gender, and education level. A partial correlation analysis was used to investigate the relationship between altered VMHC and clinical characteristics in patients with OCD.

Results: Patients with OCD showed lower VMHC than HCs in fusiform gyrus/inferior occipital gyrus, lingual gyrus, postcentral gyrus/precentral gyrus, putamen, and orbital frontal gyrus. A significant positive correlation was observed between altered VMHC in the angular gyrus/middle occipital gyrus and illness duration in patients.

Conclusions: Interhemispheric functional imbalance may be an essential aspect of the pathophysiological mechanism of OCD, which is reflected not only in the cortico-striato-thalamo-cortical (CSTC) loop but also elsewhere in the brain.

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Most cited references 51

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The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication.

A M Ruscio, D J Stein, W Chiu … (2010)

Despite significant advances in the study of obsessive-compulsive disorder (OCD), important questions remain about the disorder's public health significance, appropriate diagnostic classification, and clinical heterogeneity. These issues were explored using data from the National Comorbidity Survey Replication, a nationally representative survey of US adults. A subsample of 2073 respondents was assessed for lifetime Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV) OCD. More than one quarter of respondents reported experiencing obsessions or compulsions at some time in their lives. While conditional probability of OCD was strongly associated with the number of obsessions and compulsions reported, only small proportions of respondents met full DSM-IV criteria for lifetime (2.3%) or 12-month (1.2%) OCD. OCD is associated with substantial comorbidity, not only with anxiety and mood disorders but also with impulse-control and substance use disorders. Severity of OCD, assessed by an adapted version of the Yale-Brown Obsessive Compulsive Scale, is associated with poor insight, high comorbidity, high role impairment, and high probability of seeking treatment. The high prevalence of subthreshold OCD symptoms may help explain past inconsistencies in prevalence estimates across surveys and suggests that the public health burden of OCD may be greater than its low prevalence implies. Evidence of a preponderance of early onset cases in men, high comorbidity with a wide range of disorders, and reliable associations between disorder severity and key outcomes may have implications for how OCD is classified in DSM-V.

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Resting-state fMRI: a review of methods and clinical applications.

M Lee, C D Smyser, J Shimony (2013)

Resting-state fMRI measures spontaneous low-frequency fluctuations in the BOLD signal to investigate the functional architecture of the brain. Application of this technique has allowed the identification of various RSNs, or spatially distinct areas of the brain that demonstrate synchronous BOLD fluctuations at rest. Various methods exist for analyzing resting-state data, including seed-based approaches, independent component analysis, graph methods, clustering algorithms, neural networks, and pattern classifiers. Clinical applications of resting-state fMRI are at an early stage of development. However, its use in presurgical planning for patients with brain tumor and epilepsy demonstrates early promise, and the technique may have a future role in providing diagnostic and prognostic information for neurologic and psychiatric diseases.

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Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy.

Xi-Nian Zuo, Clare Kelly, Adriana Di Martino … (2010)

Functional homotopy, the high degree of synchrony in spontaneous activity between geometrically corresponding interhemispheric (i.e., homotopic) regions, is a fundamental characteristic of the intrinsic functional architecture of the brain. However, despite its prominence, the lifespan development of the homotopic resting-state functional connectivity (RSFC) of the human brain is rarely directly examined in functional magnetic resonance imaging studies. Here, we systematically investigated age-related changes in homotopic RSFC in 214 healthy individuals ranging in age from 7 to 85 years. We observed marked age-related changes in homotopic RSFC with regionally specific developmental trajectories of varying levels of complexity. Sensorimotor regions tended to show increasing homotopic RSFC, whereas higher-order processing regions showed decreasing connectivity (i.e., increasing segregation) with age. More complex maturational curves were also detected, with regions such as the insula and lingual gyrus exhibiting quadratic trajectories and the superior frontal gyrus and putamen exhibiting cubic trajectories. Sex-related differences in the developmental trajectory of functional homotopy were detected within dorsolateral prefrontal cortex (Brodmann areas 9 and 46) and amygdala. Evidence of robust developmental effects in homotopic RSFC across the lifespan should serve to motivate studies of the physiological mechanisms underlying functional homotopy in neurodegenerative and psychiatric disorders.

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Author and article information

Contributors

Ke Deng: URI : https://loop.frontiersin.org/people/685250

Linlin Jiang: URI : https://loop.frontiersin.org/people/468249

Yuqi Cheng: URI : https://loop.frontiersin.org/people/550933

Xiufeng Xu: URI : https://loop.frontiersin.org/people/727069

Journal

Journal ID (nlm-ta): Front Psychiatry

Journal ID (iso-abbrev): Front Psychiatry

Journal ID (publisher-id): Front. Psychiatry

Title: Frontiers in Psychiatry

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1664-0640

Publication date (Electronic): 13 June 2019

Publication date Collection: 2019

Volume: 10

Electronic Location Identifier: 418

Affiliations

[1] ¹Department of Psychiatry, First Affiliated Hospital of Kunming Medical University , Kunming, China

[2] ²Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University , Kunming, China

[3] ³Department of Rheumatology, First Affiliated Hospital of Kunming Medical University , Kunming, China

[4] ⁴Yunan Key Laboratory of Laboratory Medicine , Kunming, China

Author notes

Edited by: Paolo Brambilla, University of Milan, Italy

Reviewed by: Luke Norman, University of Michigan, United States; Gianfranco Spalletta, Fondazione Santa Lucia (IRCCS), Italy

*Correspondence: Yuqi Cheng, yuqicheng@ 123456126.com

This article was submitted to Neuroimaging and Stimulation, a section of the journal Frontiers in Psychiatry

†These authors have contributed equally to this work.

Article

DOI: 10.3389/fpsyt.2019.00418

PMC ID: 6584782

PubMed ID: 31249539

SO-VID: 6b7e833a-4485-4292-bb2c-6a09d25f0076

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 13 February 2019

Date accepted : 24 May 2019

Page count

Figures: 3, Tables: 3, Equations: 0, References: 59, Pages: 10, Words: 4333

Funding

Funded by: National Natural Science Foundation of China 10.13039/501100001809

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Reduced Interhemispheric Functional Connectivity in Obsessive–Compulsive Disorder Patients

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Abstract

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Most cited references 51

The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication.

Resting-state fMRI: a review of methods and clinical applications.

Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy.

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Cited by 9

Most referenced authors 819