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      Technology innovation to reduce health inequality in skin diagnosis and to improve patient outcomes for people of color: a thematic literature review and future research agenda

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          Abstract

          The health inequalities experienced by ethnic minorities have been a persistent and global phenomenon. The diagnosis of different types of skin conditions, e.g., melanoma, among people of color is one of such health domains where misdiagnosis can take place, potentially leading to life-threatening consequences. Although Caucasians are more likely to be diagnosed with melanoma, African Americans are four times more likely to present stage IV melanoma due to delayed diagnosis. It is essential to recognize that additional factors such as socioeconomic status and limited access to healthcare services can be contributing factors. African Americans are also 1.5 times more likely to die from melanoma than Caucasians, with 5-year survival rates for African Americans significantly lower than for Caucasians (72.2% vs. 89.6%). This is a complex problem compounded by several factors: ill-prepared medical practitioners, lack of awareness of melanoma and other skin conditions among people of colour, lack of information and medical resources for practitioners’ continuous development, under-representation of people of colour in research, POC being a notoriously hard to reach group, and ‘whitewashed’ medical school curricula. Whilst digital technology can bring new hope for the reduction of health inequality, the deployment of artificial intelligence in healthcare carries risks that may amplify the health disparities experienced by people of color, whilst digital technology may provide a false sense of participation. For instance, Derm Assist, a skin diagnosis phone application which is under development, has already been criticized for relying on data from a limited number of people of color. This paper focuses on understanding the problem of misdiagnosing skin conditions in people of color and exploring the progress and innovations that have been experimented with, to pave the way to the possible application of big data analytics, artificial intelligence, and user-centred technology to reduce health inequalities among people of color.

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          Most cited references44

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          Dissecting racial bias in an algorithm used to manage the health of populations

          Health systems rely on commercial prediction algorithms to identify and help patients with complex health needs. We show that a widely used algorithm, typical of this industry-wide approach and affecting millions of patients, exhibits significant racial bias: At a given risk score, Black patients are considerably sicker than White patients, as evidenced by signs of uncontrolled illnesses. Remedying this disparity would increase the percentage of Black patients receiving additional help from 17.7 to 46.5%. The bias arises because the algorithm predicts health care costs rather than illness, but unequal access to care means that we spend less money caring for Black patients than for White patients. Thus, despite health care cost appearing to be an effective proxy for health by some measures of predictive accuracy, large racial biases arise. We suggest that the choice of convenient, seemingly effective proxies for ground truth can be an important source of algorithmic bias in many contexts.
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            A deep learning system for differential diagnosis of skin diseases

            Skin conditions affect 1.9 billion people. Because of a shortage of dermatologists, most cases are seen instead by general practitioners with lower diagnostic accuracy. We present a deep learning system (DLS) to provide a differential diagnosis of skin conditions using 16,114 de-identified cases (photographs and clinical data) from a teledermatology practice serving 17 sites. The DLS distinguishes between 26 common skin conditions, representing 80% of cases seen in primary care, while also providing a secondary prediction covering 419 skin conditions. On 963 validation cases, where a rotating panel of three board-certified dermatologists defined the reference standard, the DLS was non-inferior to six other dermatologists and superior to six primary care physicians (PCPs) and six nurse practitioners (NPs) (top-1 accuracy: 0.66 DLS, 0.63 dermatologists, 0.44 PCPs and 0.40 NPs). These results highlight the potential of the DLS to assist general practitioners in diagnosing skin conditions.
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              Receiver operating characteristic curve: overview and practical use for clinicians

              Using diagnostic testing to determine the presence or absence of a disease is essential in clinical practice. In many cases, test results are obtained as continuous values and require a process of conversion and interpretation and into a dichotomous form to determine the presence of a disease. The primary method used for this process is the receiver operating characteristic (ROC) curve. The ROC curve is used to assess the overall diagnostic performance of a test and to compare the performance of two or more diagnostic tests. It is also used to select an optimal cut-off value for determining the presence or absence of a disease. Although clinicians who do not have expertise in statistics do not need to understand both the complex mathematical equation and the analytic process of ROC curves, understanding the core concepts of the ROC curve analysis is a prerequisite for the proper use and interpretation of the ROC curve. This review describes the basic concepts for the correct use and interpretation of the ROC curve, including parametric/nonparametric ROC curves, the meaning of the area under the ROC curve (AUC), the partial AUC, methods for selecting the best cut-off value, and the statistical software to use for ROC curve analyses.
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                Author and article information

                Contributors
                URI : https://loop.frontiersin.org/people/2372040/overviewRole: Role:
                URI : https://loop.frontiersin.org/people/580457/overviewRole: Role:
                URI : https://loop.frontiersin.org/people/2265276/overviewRole: Role:
                Journal
                Front Artif Intell
                Front Artif Intell
                Front. Artif. Intell.
                Frontiers in Artificial Intelligence
                Frontiers Media S.A.
                2624-8212
                13 June 2024
                2024
                : 7
                : 1394386
                Affiliations
                College of Engineering, Design and Physical Science, Brunel Design School, Brunel University London , Uxbridge, United Kingdom
                Author notes

                Edited by: Kezhi Li, University College London, United Kingdom

                Reviewed by: Laurent Moccozet, University of Geneva, Switzerland

                Antonio Sarasa-Cabezuelo, Complutense University of Madrid, Spain

                *Correspondence: Gabriella Spinelli, gabriella.spinelli@ 123456brunel.ac.uk
                Article
                10.3389/frai.2024.1394386
                11209749
                38938325
                6aba6b38-5ba7-41ca-a186-d009f37e028d
                Copyright © 2024 Khatun, Spinelli and Colecchia.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 01 March 2024
                : 27 May 2024
                Page count
                Figures: 2, Tables: 1, Equations: 0, References: 60, Pages: 11, Words: 8617
                Funding
                The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. Brunel University London funded the publication of this study.
                Categories
                Artificial Intelligence
                Review
                Custom metadata
                Medicine and Public Health

                dermatology,artificial intelligence,skin of color,people of color,ethnic minorities,data augmentation,health inequalities

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