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      Copper and Zinc Nutritional Issues for Agricultural Animal Production

      review-article
      1 , , 2
      Biological Trace Element Research
      Springer US
      Copper, Zinc, Livestock production

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          Abstract

          Livestock have presented unique requirements and toxicity issues depending on the species for the various concentrations of Cu and Zn and their interactions with other nutrients especially Fe, Se, Mo, and S. Soil concentrations of these elements and their availability to crops influence the health of the crop and the amount found in vegetative tissues and seeds. Hence, many livestock issues are a result of the soils in the area where production is occurring (Loneragan et al. 1981). While water can provide minerals to animals, the amount consumed and availability are highly variable. Many discoveries about Cu were a result of low Cu concentrations and its availability due to interactions with other nutrients in the soils. Anemia, bone disorders, cardiovascular abnormalities, defective wool and hair, and infertility are signs/symptoms of Cu deficiency. Toxicity due to excess Cu is more likely to occur in sheep than other farm species. Swine are tolerant of high concentrations of dietary Cu, and it is often used as a growth stimulant in production. There are many species and physiological stages where the animal’s Cu requirement is not known. Grazing animals can exhibit Zn deficiency when soils and forages contain limited concentrations of Zn. Pastures have been observed to be Zn-deficient in many parts of the world. However, non-ruminant animals usually receive adequate Zn when fed corn and soybean meal diets if there is not excessive Ca and Fe in their diets, but this is not true for rapidly growing young animals. Characteristics of a Zn deficiency include loss of appetite, reduced growth and reproduction, and impaired health of bone and skin tissues.

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          Most cited references130

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          Growth promotion effects and plasma changes from feeding high dietary concentrations of zinc and copper to weanling pigs (regional study).

          An experiment was conducted to determine the effect of high dietary intakes of Zn and Cu and their combination on growth performance of weanling pigs with diverse health status and management strategies. Twelve experiment stations cooperated and used a total of 1,356 pigs that averaged 6.55 kg BW and 22.2 d age at weaning. The four dietary treatments, all of which met or exceeded NRC requirements, were 1) control, 2) 3,000 ppm Zn (from Zn oxide), 3) 250 Cu ppm (from Cu sulfate), or 4) 3,000 ppm Zn and 250 ppm Cu. The diets were fed as a complex Phase I diet (1.4% lysine) for 7 d followed by a Phase II diet (1.2% lysine) for 21 d. Chlortetracycline (220 ppm) was added to all diets. Fecal color (1 = yellow to 5 = black) and consistency (1 = very firm to 5 = very watery) were scored daily for 3 wk. At the end of the 28-d study, 412 pigs were bled at five stations, and plasma Cu, Zn, and Fe concentrations were determined at one station with atomic absorption spectrophotometry. Average daily gain (375, 422, 409, 415 g/d), feed intake (637, 690, 671, 681 g/d), and gain/feed (586, 611, 611, 612 g/kg) were improved (P < .01) by the addition of Zn and(or) Cu. Significant Cu x Zn interactions imply that the responses to Zn and Cu were independent and not additive. There were significant (P < .01) Zn and Cu effects and a Zn x Cu interaction on fecal color (3.17, 3.24, 4.32, 3.57) and consistency (2.39, 2.14, 2.14, 2.13). Dietary additions of Cu and Zn resulted in elevated plasma concentrations of Cu and Zn, respectively. These data indicate that pharmacological additions of 3,000 ppm Zn (oxide) or 250 ppm Cu (sulfate) stimulate growth beyond that derived from intakes of Zn and Cu that meet nutrient requirements. However, the combination of Zn and Cu did not result in an additive growth response.
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            Early- and traditionally weaned nursery pigs benefit from phase-feeding pharmacological concentrations of zinc oxide: effect on metallothionein and mineral concentrations.

            Benefits of feeding pharmacological concentrations of zinc (Zn) provided by Zn oxide (ZnO) to 21-d conventionally weaned pigs in the nursery have been documented; however, several management questions remain. We conducted two experiments to evaluate the effect on growth from feeding 3,000 ppm Zn as ZnO during different weeks of the nursery period. In Exp. 1 (n = 138, 11.5 d of age, 3.8 kg BW) and Exp. 2 (n = 246, 24.5 d of age, 7.2 kg BW), pigs were fed either basal diets containing 100 ppm supplemental Zn (adequate) or the same diet with an additional 3,000 ppm Zn (high) supplied as ZnO. Pigs were fed four or two dietary phases in Exp. 1 and 2, respectively, that changed in dietary ingredients and nutrient content (lysine and crude protein) to meet the changing physiological needs of the pigs for the 28-d nursery period. Dietary Zn treatments were 1) adequate Zn fed wk 1 to 4, 2) high Zn fed wk 1, 3) high Zn fed wk 2, 4) high Zn fed wk 1 and 2, 5) high Zn fed wk 2 and 3, and 6) high Zn fed wk 1 to 4. In Exp. 1 and 2, pigs fed high Zn for wk 1 and 2 or the entire 28-d nursery period had the greatest (P < .05) ADG. During any week, pigs fed high Zn had greater concentrations of hepatic metallothionein and Zn in plasma, liver, and kidney than those pigs fed adequate Zn (P < .05). In summary, both early- and traditionally weaned pigs need to be fed pharmacological concentrations of Zn provided as ZnO for a minimum of 2 wk immediately after weaning to enhance growth.
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              Effect of zinc source (zinc oxide vs zinc proteinate) and level on performance, carcass characteristics, and immune response of growing and finishing steers.

              Sixty Angus and Angus x Hereford steers (246 kg initial BW) were used to determine the effects of Zn level and source on performance, immune response, and carcass characteristics of growing and finishing steers. Treatments consisted of 1) control (no supplemental Zn), 2) ZnO, 3) Zn proteinate-A (ZnProt-A, 10% Zn), and 4) ZnProt-B (15% Zn). Treatments 2, 3, and 4 supplied 25 mg of supplemental Zn/kg diet. Steers were individually fed a corn silage-based diet during the 84-d growing phase and a high corn diet during the finishing phase. Cell-mediated and humoral immune response measurements were obtained between d 67 and 74 of the growing phase. Equal number of steers per treatment were slaughtered after receiving the finishing diets for 84 or 112 d. Performance and carcass measurements were similar in steers fed the two ZnProt sources. Zinc supplementation, regardless of source, increased (P < 0.05) ADG during the growing phase. In the finishing phase, ADG (P = 0.10) and gain/feed (P = 0.07) tended to be higher for steers fed ZnProt compared with those supplemented with ZnO. Gain and feed efficiency were similar for control and ZnO-supplemented steers during the finishing phase. Steers fed ZnProt had heavier (P < 0.05) hot carcass weights and slightly higher (P < 0.05) dressing percentages than those in the control or ZnO treatments. Quality grade, yield grade, marbling, and backfat were increased by Zn supplementation, but were not affected by Zn source. In vitro response of lymphocytes to mitogen stimulation and in vivo swelling response following intradermal injection of phytohemagglutinin were not affected by Zn level or source. Humoral immune response following vaccination with infectious bovine rhinotracheitis also was not affected by treatment. Soluble concentrations of Zn in ruminal fluid were higher (P < 0.05) in steers fed ZnProt compared to ZnO steers. Results indicate that ZnProt may improve performance of finishing steers above that observed with inorganic Zn supplementation.
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                Author and article information

                Contributors
                517-355-9676 , hillgre@msu.edu
                573-882-7859 , carlsonm@missouri.edu
                Journal
                Biol Trace Elem Res
                Biol Trace Elem Res
                Biological Trace Element Research
                Springer US (New York )
                0163-4984
                1559-0720
                5 January 2019
                5 January 2019
                2019
                : 188
                : 1
                : 148-159
                Affiliations
                [1 ]ISNI 0000 0001 2150 1785, GRID grid.17088.36, Department of Animal Science, , Michigan State University, ; East Lansing, MI USA
                [2 ]ISNI 0000 0001 2162 3504, GRID grid.134936.a, Division of Animal Science, , University of Missouri, ; Columbia, MO USA
                Article
                1578
                10.1007/s12011-018-1578-5
                6373331
                30612303
                6a09099a-c1a4-471f-a3c1-06d286c913a8
                © The Author(s) 2019

                Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 4 October 2018
                : 9 November 2018
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                © Springer Science+Business Media, LLC, part of Springer Nature 2019

                Biochemistry
                copper,zinc,livestock production
                Biochemistry
                copper, zinc, livestock production

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